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. 2023 Aug 15;9(5):e200093. doi: 10.1212/NXG.0000000000200093

Figure 2. Enzymatic in Vitro Test.

Figure 2

Basal ATPase activity was determined from purified recombinant VCP protein. Values are normalized to VCP-wild type activity and presented as percent change from VCP-wild type. Red bars represent known pathogenic variants. Green bars represent known benign variants. Yellow bars represent the novel variants investigated. The dotted line represents the 3-fold increase threshold in ATPase activity consistent with a dysfunctional variant. ns: nonsignificant difference. **p < 0.05; ****p < 0.0001. VCP = valosin-containing protein.