Figure 1.

Schematic illustration of synthesis of dECM/GP hydrogel and application for post‐MI cardiac repair. To prepare dECM/GP hydrogel, MAL‐GM is synthesized through esterification. Then KK peptide and dECM are chemically conjugated to MAL‐GM by Michael addition between sulfhydryl and maleimide group. dECM/GP hydrogel conforming to “HELP” strategy can act as an immunomodulatory niche by attracting host cell infiltration with microstructure and ECM ingredients, controlling macrophage differentiation with GP unit, and promoting endotheliocyte (EC) proliferation through VEGF‐MAPK pathway, as a whole for cardiac repair post MI.