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. 2023 Jul 31;29(8):2133–2141. doi: 10.1038/s41591-023-02465-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — ^a‘CLDN18.2-positive’ was defined as ≥75% of tumor cells with moderate-to-strong membranous CLDN18 staining as determined by central immunohistochemistry using the investigational VENTANA CLDN18 (43-14A) RxDx Assay. ^b‘Other’ represents patients whose tumors were CLDN18.2-positive but failed screening for other reasons, including laboratory findings, HER2 expression status, Eastern Cooperative Oncology Group (ECOG) performance status score, other exclusion criteria or withdrawal by patient. ^cIf patients discontinued from both zolbetuximab or placebo and CAPOX on the same day, all reasons for discontinuation were summarized; the sum of values for individual reasons for discontinuation is more than 212 for the zolbetuximab group and more than 213 for the placebo group. ^dOne patient randomized to the placebo plus CAPOX group received one dose of zolbetuximab as a protocol deviation and was moved to the zolbetuximab plus CAPOX group for the safety analysis set.