Table 1.
Characteristics of AD/LB groups
| Variable | AD–/LB– (n = 941) | AD–/LB+ (n = 74) | AD+/LB– (n = 147) | AD+/LB+ (n = 20) | Total (n = 1,182) |
|---|---|---|---|---|---|
| Age, years | 69 (9.1) | 73 (7.4) | 73 (5.7) | 75 (4.4) | 70 (8.8) |
| Education, years | 12 (3.4) | 12 (3.2) | 12 (3.6) | 13 (4.7) | 12 (3.5) |
| Sex, n female | 572 (60.8%) | 30 (40.5%) | 89 (60.5%) | 7 (35.0%) | 698 (59.1%) |
| MMSE, points | 29 (1.1) | 29 (1.3) | 29 (1.2) | 28 (1.6) | 29 (1.1) |
| Global cognition (z-score) | 0.056 (0.75) | −0.470 (0.80) | −0.630 (0.83) | −0.940 (0.79) | −0.070 (0.81) |
| Memory (z-score) | −0.014 (0.99) | −0.560 (1.2) | −0.630 (1.3) | −1.000 (0.87) | −0.140 (1.1) |
| Attention/executive (z-score) | −0.056 (0.91) | −0.390 (0.86) | −0.440 (0.86) | −0.600 (0.96) | −0.130 (0.91) |
| Smell function (z-score) | 0.000 (0.96) | −1.300 (1.3) | −0.045 (0.77) | −0.990 (0.53) | −0.090 (1.0) |
| Motor function (CIMP-QUEST, z-score) | 0.010 (0.91) | −0.650 (1.4) | −0.380 (1.2) | −0.054 (0.60) | −0.082 (1.0) |
| Motor function (UPDRS-III, z-score) | 0.066 (0.97) | −0.110 (1.2) | −0.220 (1.0) | −0.730 (1.0) | −0 (1.0) |
| Signs of REM sleep disorder, na | 24 (2.6%)a | 7 (9.5%)a | 2 (1.4%)a | 0 (0%)a | 33 (2.8%)a |
| A/T/LB, n | |||||
| A–/T–/LB– | 795 (84.5%) | 0 (0%) | 0 (0%) | 0 (0%) | 795 (67.3%) |
| A–/T+/LB– | 27 (2.9%) | 0 (0%) | 0 (0%) | 0 (0%) | 27 (2.3%) |
| A+/T–/LB– | 119 (12.6%) | 0 (0%) | 0 (0%) | 0 (0%) | 119 (10.1%) |
| A–/T–/LB+ | 0 (0%) | 55 (74.3%) | 0 (0%) | 0 (0%) | 55 (4.7%) |
| A–/T+/LB+ | 0 (0%) | 1 (1.4%) | 0 (0%) | 0 (0%) | 1 (0.1%) |
| A+/T–/LB+ | 0 (0%) | 18 (24.3%) | 0 (0%) | 0 (0%) | 18 (1.5%) |
| A+/T+/LB– | 0 (0%) | 0 (0%) | 147 (100%) | 0 (0%) | 147 (12.4%) |
| A+/T+/LB+ | 0 (0%) | 0 (0%) | 0 (0%) | 20 (100%) | 20 (1.7%) |
| CSF Aβ42/Aβ40 | 0.095 (0.022) | 0.087 (0.024) | 0.043 (0.0097) | 0.039 (0.0081) | 0.087 (0.028) |
| Aβ-PET (SUVR)b | 0.50 (0.093) | 0.54 (0.11) | 0.81 (0.11) | 0.83 (0.061) | 0.52 (0.12) |
| CSF P-tau217 (pg ml–1) | 5.9 (2.7) | 7.1 (3.9) | 26 (16) | 43 (35) | 10 (12) |
| Tau-PET (SUVR)c | 1.1 (0.092) | 1.1 (0.097) | 1.6 (0.400) | 2.1 (0.630) | 1.2 (0.190) |
| CSF α-syn SAA positivity (LB pathology), n | 0 (0%) | 74 (100%) | 0 (0%) | 20 (100%) | 94 (8.0%) |
Data are shown as mean (s.d.) unless otherwise specified. Note that tau-PET and Aβ-PET data are from BioFINDER-2 only, and CSF P-tau217 and CSF Aβ42/Aβ40 are from BioFINDER-1.
aBased on whether the participant had been told that he/she seems to ‘act out his/her dreams’48. Data available only for BioFINDER-2.
bMeasured in a composite neocortical ROI using [18F]flutemetamol with pons as reference region.
cMeasured in a temporal meta-ROI using [18F]RO948 with inferior cerebellar cortex as reference region46.