Extended Data Fig. 4. Changes in circulating surrogate tumor markers correlate with radiographic tumor response.
SMRP was measured in plasma using the Mesomark™ assay and MPF was measured in plasma using an ECL assay and ctDNA was measured using a plasma based NGS assay. Comparative analysis of a, best SMRP response (n = 25 independent patient samples, **p = 0.074 by two-tailed Mann Whitney t test. and b, best MPF response in responders vs. non-responders. (n = 29 independent patient samples). For both a, and b, patients classified as non-evaluable by RECIST response were excluded from the analysis. For both box-plots; center line, box limits and whiskers represent the median, interquartile range and minima and maxima, respectively. c, Longitudinal changes in ctDNA levels in selected patients.