Table 2. Changes in HIV-1 subtypes/sub-subtypes among Chinese individuals naïve to ART across various stages of the NFATP from 2004 to 2022.
| HIV-1 subtype/sub-subtype | 2004–2007 | 2008–2011 | 2012–2015 | 2016–2019 | 2020–2022 | P * | Total | ||||||||||
| N † | %§ | N | % | N | % | N | % | N | % | N | % | ||||||
| Abbreviation: ART=antiretroviral therapy; HIV=human immunodeficiency virus; NFATP=National Free Antiretroviral Treatment Program; CRF=circulating recombinant form; URFs=unique recombinant forms. * P values were calculated using Cochran-Armitage trend test. P values <0.05 is statistically significant. † Number of ART-naïve individuals infected with HIV surveyed. § Proportions of ART-naïve individuals infected with HIV. | |||||||||||||||||
| Total | 1,251 | 100.0 | 8,794 | 100.0 | 21,467 | 100.0 | 21,391 | 100.0 | 4,999 | 100.0 | 57,902 | 100.0 | |||||
| CRF01_AE | 467 | 37.3 | 3,911 | 44.5 | 9,049 | 42.2 | 7,906 | 37.0 | 1,472 | 29.4 | <0.001 | 22,805 | 39.4 | ||||
| CRF01_AE-cluster 1 | 166 | 13.3 | 763 | 8.7 | 1,155 | 5.4 | 1,276 | 6.0 | 210 | 4.2 | <0.001 | 3,570 | 6.2 | ||||
| CRF01_AE-cluster 2 | 31 | 2.5 | 389 | 4.4 | 388 | 1.8 | 1,424 | 6.7 | 108 | 2.2 | <0.001 | 2,340 | 4.0 | ||||
| CRF01_AE-cluster 3 | 13 | 1.0 | 40 | 0.5 | 97 | 0.5 | 193 | 0.9 | 34 | 0.7 | <0.001 | 377 | 0.7 | ||||
| CRF01_AE-cluster 4 | 101 | 8.1 | 1,740 | 19.8 | 5,397 | 25.1 | 2,960 | 13.8 | 681 | 13.6 | <0.001 | 10,879 | 18.8 | ||||
| CRF01_AE-cluster 5 | 64 | 5.1 | 589 | 6.7 | 1,469 | 6.8 | 1,485 | 6.9 | 335 | 6.7 | 0.205 | 3,942 | 6.8 | ||||
| CRF01_AE-cluster 6 | 6 | 0.5 | 14 | 0.2 | 23 | 0.1 | 9 | 0.0 | 3 | 0.1 | <0.001 | 55 | 0.1 | ||||
| CRF01_AE-cluster 7 | 6 | 0.5 | 31 | 0.4 | 40 | 0.2 | 17 | 0.1 | 1 | 0.0 | <0.001 | 95 | 0.2 | ||||
| CRF01_AE-other | 80 | 6.4 | 345 | 3.9 | 480 | 2.2 | 542 | 2.5 | 100 | 2.0 | <0.001 | 1,547 | 2.7 | ||||
| CRF07_BC | 301 | 24.1 | 2,540 | 28.9 | 7,397 | 34.5 | 8,194 | 38.3 | 2,038 | 40.8 | <0.001 | 20,470 | 35.4 | ||||
| CRF07_BC-MSM | 68 | 5.4 | 1,261 | 14.3 | 5,353 | 24.9 | 4,412 | 20.6 | 1,217 | 24.3 | <0.001 | 12,311 | 21.3 | ||||
| CRF07_BC-other | 233 | 18.6 | 1,279 | 14.5 | 2,044 | 9.5 | 3,782 | 17.7 | 821 | 16.4 | <0.001 | 8,159 | 14.1 | ||||
| CRF08_BC | 144 | 11.5 | 390 | 4.4 | 1,191 | 5.5 | 2,097 | 9.8 | 577 | 11.5 | <0.001 | 4,399 | 7.6 | ||||
| CRF55_01B | 1 | 0.1 | 221 | 2.5 | 1,170 | 5.5 | 1,125 | 5.3 | 189 | 3.8 | <0.001 | 2,706 | 4.7 | ||||
| B | 301 | 24.1 | 1,223 | 13.9 | 1,652 | 7.7 | 967 | 4.5 | 364 | 7.3 | <0.001 | 4,507 | 7.8 | ||||
| C | 16 | 1.3 | 128 | 1.5 | 113 | 0.5 | 105 | 0.5 | 12 | 0.2 | <0.001 | 374 | 0.6 | ||||
| Other subtypes | 5 | 0.4 | 52 | 0.6 | 80 | 0.4 | 78 | 0.4 | 24 | 0.5 | 0.179 | 239 | 0.4 | ||||
| Other CRFs | 5 | 0.4 | 197 | 2.2 | 398 | 1.9 | 489 | 2.3 | 183 | 3.7 | <0.001 | 1,272 | 2.2 | ||||
| URFs | 11 | 0.9 | 132 | 1.5 | 417 | 1.9 | 430 | 2.0 | 140 | 2.8 | <0.001 | 1,130 | 2.0 | ||||