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. 2023 Aug 1;14:1230174. doi: 10.3389/fphar.2023.1230174

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Copyright © 2023 Yan, Zhou, Meng, Zhou, Jia, Li, Cui, Yu, Tang, Li, Zhang, Wang, Hou and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene expression change of synovium fibroblasts after CD36 knockdown. (A–C) A total of 158 mRNA were differently expressed (Fold Change ≥2 and Adjusted p-value ≤0.001) between siRNA group and the control group, among which 81 were upregulated and 77 were down-regulated. (D) KEGG pathway analysis was performed to determine the pivotal signaling pathways within the differentially expressed genes. (E) GO analysis was performed to investigate the vital change of cell function after knocking down the CD36 gene in synovial fibroblast.