Fig. 2.

Geographical spread of studies included in the review. Geographic spread of studies reporting different outcomes in the literature review. Bubble size scaled to represent number of studies. International studies are recorded in multiple countries, aligned with their participating centres. Patient HRQoL: Germany, n = 7; US, n = 5; Japan and Spain, n = 3; Australia and Turkey, n = 2; Austria, Brazil, Denmark, Finland, Italy, South Korea, Sweden and UK, n = 1. Caregiver QoL: Germany, n = 4; Spain, n = 3; Japan and US, n = 2; Argentina, Australia, Brazil, Colombia, France, Italy, Turkey and UK, n = 1. Healthcare cost and resource use: Italy and Spain, n = 2; Argentina, Austria, Brazil, Colombia, Denmark, France, Germany, Japan, Sweden and US, n = 1. Clinical evidence: Japan, n = 12; US, n = 7; UK, n = 5; Italy and Turkey, n = 4; Australia and South Korea, n = 3; France and Germany, n = 2; Denmark, Finland, Greece, Hong Kong, Israel, Norway, Poland, Spain and Sweden, n = 1. Treatment guidelines: US, n = 7; Australia, Canada, France and Japan, n = 2; Brazil, China, Denmark, Germany, India, New Zealand, Portugal, South Africa, Sweden, The Netherlands and UK, n = 1