Fig. 4.

Mean change in height reported across studies. Legend: Mean change in A standing height, B height Z-score from baseline following intervention. A favourable effect on change in height was reported for all ifentified inteventions. However, outcomes were reported over different time periods for the therapies. For vosoritide, outcomes were measured at 2–5 years; for GH, outcomes were measured at 5–10.7 years; for limb lengthening, outcomes were measured from 6 months to 5 years. Included studies: Study 111-202 [58] and extension Study 111-205 [59]; Study 111-301 [36] and extension Study 111-302 [60]; Hertel [65]; Harada [68]; Price [73]; Peretti [69]; Kocaoğlu [76]; Kadono [77]; Donaldson [70]; Devmurari [75]; De Bastini [71]; Bridgman [80]; Aldegheri [74]. GH growth hormone, LL limb lengthening, rhGH recombinant human growth hormone