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. 2023 Aug 15;14:4942. doi: 10.1038/s41467-023-40662-7

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Heatmap of the top 5 markers in primitive and definitive neutrophils at steady state (complete list available in Supplementary Data 2, filtered on a minimum detection fraction threshold = 0.1, log fold-change threshold = 0.25 and p-value < 0.05 (not adjusted), negative binomial test, out of the 2000 most variable genes, only genes with positive fold change were selected). B, C Heatmaps of the top 15 upregulated and downregulated genes upon tail resection among the RBI- derived (B) and CHT-derived (C) neutrophil populations (complete list available in Supplementary Data 3 and 4, filtered on a minimum detection fraction threshold = 0.1, log fold-change threshold = 0.25 and p-value < 0.05 (not adjusted), negative binomial test, out of the 2000 most variable genes, only genes with positive fold change were selected). D Venn diagram showing the number of overlapping upregulated and downregulated genes between RBI-derived and CHT-derived neutrophils. E Network of the pathways associated with upregulated and downregulated genes among RBI-derived and CHT-derived neutrophils upon tail resection. Each gene associated with a given pathway is displayed. Pie charts indicated the relative contribution of each type of neutrophil to that term/gene (see Methods). Note that csf3b appears both as associated with chemotaxis upon resection and as a specific marker of the RBI-derived neutrophils when compared with CHT-derived neutrophils. Heatmaps show genes with p-value < 0.05, based on a negative binomial distribution, out of the 2000 most variable genes.