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. 2023 Aug 15;13:283. doi: 10.1038/s41398-023-02581-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A FMRI Task Design: all participants underwent the same measurement regimen including two MRI sessions separated by two days. Anxiety or neutral words were presented either on day one or day two depending on the randomization. Participants with anorexia nervosa saw a set of personalized anxiety-eliciting words related to food while the control group saw a set of personalized general anxiety-eliciting words. During the neutral condition, participants were shown a set of personalized neutral stimuli. During each scanning day 60 words were presented, which were displayed for two seconds on the screen. (Of note, the word presentations shown here were part of a larger paradigm where people were also presented with additional stimuli to assess reward processing and reaction times.). B Calculation of Individual Brain Responses to Each Stimulus. Brain responses for each stimulus were calculated by using the beta-map derived from least-square-sum estimates. All 120 beta-maps (anxiety and neutral conditions) for each participant were normalized to standard Montreal Neurological Institute (MNI) space and forwarded to representational similarity analysis (RSA).