Table 2.
Meta-analysis of circRNA differentially expressed between AD and controls in the hippocampus and cortex at FDR<0.05 (n=48).
| circRNA | Meta results (BU+BM44) | BM44 Cortex (AD vs. Ctrl) | BU Hippocampus (pureAD vs.Ctrl) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Coordinates (hg38) | Name | P. value | Dir | FDR | log2 FC | Ave Expr | P. Value | log2 FC | Ave Expr | P. Value |
| chr15:72760406-72775097 | ADPGK | 2.08E-07 | −− | 0.001 | −0.35 | 1.00 | 2.54E-04 | −0.47 | −0.14 | 4.75E-05 |
| chr5:59180594-59215968 | PDE4D | 6.29E-07 | −− | 0.001 | −0.39 | 1.98 | 1.50E-05 | −0.41 | 0.85 | 1.36E-02 |
| chr14:46920011-47035304 | MDGA2 | 5.37E-06 | −− | 0.005 | −0.34 | 1.34 | 2.55E-04 | −0.42 | 0.17 | 5.59E-03 |
| chr10:115426249-115549536 | ATRNL1 | 1.29E-05 | −− | 0.008 | −0.37 | 1.82 | 1.25E-04 | −0.33 | −0.06 | 3.77E-02 |
| chr7:66240324-66241270 | TPST1 | 1.55E-05 | −− | 0.008 | −0.37 | 0.54 | 1.75E-04 | −0.28 | −0.18 | 3.20E-02 |
| chr1:9871186-9877989 | CTNNBIP1 | 3.79E-05 | −− | 0.016 | −0.32 | 0.56 | 5.50E-05 | −0.18 | −0.27 | 2.14E-01 |
| chr2:106830065-106844034 | ST6GAL2 | 4.45E-05 | −− | 0.016 | −0.43 | 2.63 | 5.50E-05 | −0.31 | 0.93 | 2.43E-01 |
| chr10:92893348-92920050 | EXOC6 | 5.83E-05 | −? | 0.019 | −0.37 | 0.95 | 5.83E-05 | NA | NA | NA |
| chr15:91251818-91268605 | SV2B | 6.70E-05 | −− | 0.019 | −0.40 | 1.64 | 1.78E-05 | −0.10 | 0.47 | 6.02E-01 |
| chr10:21904521-21920963 | DNAJC1 | 7.90E-05 | −− | 0.019 | −0.34 | 1.13 | 1.89E-04 | −0.17 | −0.18 | 1.55E-01 |
| chr7:157656356-157682937 | PTPRN2 | 8.16E-05 | −− | 0.019 | −0.34 | 0.20 | 7.03E-04 | −0.30 | −0.10 | 4.43E-02 |
| chr8:53795646-53801896 | ATP6V1H | 9.60E-05 | −− | 0.020 | −0.32 | 0.58 | 2.38E-04 | −0.17 | −0.34 | 1.53E-01 |
| chrX:32287528-32348528 | DMD | 1.10E-04 | −− | 0.020 | −0.32 | 1.64 | 7.26E-04 | −0.36 | 0.93 | 6.01E-02 |
| chr1:65913244-65918835 | PDE4B | 1.11E-04 | −+ | 0.020 | −0.46 | 3.11 | 8.18E-06 | 0.00 | 0.56 | 9.85E-01 |
| chr2:2836918-2839025 | AC011995.2 | 1.59E-04 | −? | 0.025 | −0.37 | 1.10 | 1.59E-04 | NA | NA | NA |
| chr1:585033-855380 | AKT3 | 1.59E-04 | −− | 0.025 | −0.30 | 0.95 | 4.57E-04 | −0.20 | 0.37 | 1.40E-01 |
| chr6:88844356-88891915 | RNGTT | 1.63E-04 | −? | 0.025 | −0.33 | 0.55 | 1.63E-04 | NA | NA | NA |
| chr13:100307191-100449305 | PCCA | 2.15E-04 | −? | 0.031 | −0.39 | 0.63 | 2.15E-04 | NA | NA | NA |
| chr6:61606289-61697253 | KHDRBS2 | 2.34E-04 | −− | 0.031 | −0.29 | 2.21 | 7.93E-04 | −0.25 | 0.49 | 1.23E-01 |
| chr4:30920152-30950215 | PCDH7 | 2.39E-04 | −− | 0.031 | −0.24 | 1.36 | 6.29E-03 | −0.36 | −0.01 | 8.63E-03 |
| chr2:135709432-135710231 | R3HDM1 | 3.07E-04 | −− | 0.034 | −0.30 | 1.12 | 3.08E-04 | −0.13 | −0.04 | 3.38E-01 |
| chr5:109767534-109823837 | MAN2A1 | 3.12E-04 | ++ | 0.034 | 0.45 | 2.32 | 7.49E-05 | 0.10 | 2.37 | 7.40E-01 |
| chr5:180261683-180280608 | MAPK9 | 3.12E-04 | −− | 0.034 | −0.30 | 2.54 | 1.25E-03 | −0.23 | 0.86 | 1.06E-01 |
| chr12:51684173-51689096 | SCN8A | 3.19E-04 | −? | 0.034 | −0.36 | 0.82 | 3.18E-04 | NA | NA | NA |
| chr6:68943829-69018499 | ADGRB3 | 3.64E-04 | −− | 0.036 | −0.33 | 1.03 | 4.02E-04 | −0.13 | −0.15 | 3.22E-01 |
| chr4:61909559-61998265 | ADGRL3 | 3.76E-04 | −? | 0.036 | −0.32 | 0.70 | 3.75E-04 | NA | NA | NA |
| chr5:11082695-11098748 | CTNND2 | 3.87E-04 | −− | 0.036 | −0.36 | 0.89 | 7.07E-05 | −0.03 | 0.11 | 8.46E-01 |
| chr20:41533049-41551360 | CHD6 | 3.88E-04 | −− | 0.036 | −0.27 | 1.61 | 1.89E-03 | −0.23 | 0.64 | 8.66E-02 |
| chr2:199308759-199381820 | SATB2 | 4.05E-04 | −− | 0.036 | −0.32 | 1.82 | 1.63E-04 | −0.11 | 0.55 | 5.97E-01 |
| chr6:72307257-72333835 | RIMS1 | 4.58E-04 | −− | 0.038 | −0.27 | 5.11 | 2.09E-03 | −0.31 | 4.26 | 9.35E-02 |
| chr9:98385639-98406141 | GABBR2 | 4.61E-04 | −? | 0.038 | −0.36 | 0.57 | 4.61E-04 | NA | NA | NA |
| chr18:46946056-46946923 | KATNAL2 | 4.70E-04 | −− | 0.038 | −0.44 | 2.21 | 6.23E-05 | −0.01 | 1.66 | 9.70E-01 |
| chr8:80499493-80500382 | ZBTB10 | 4.90E-04 | −− | 0.038 | −0.28 | 0.80 | 2.41E-03 | −0.24 | 0.04 | 8.61E-02 |
| chr6:70732377-70798737 | SMAP1 | 5.04E-04 | −− | 0.038 | −0.29 | 1.06 | 1.39E-03 | −0.20 | 0.22 | 1.56E-01 |
| chr7:22291174-22318037 | RAPGEF5 | 5.27E-04 | −− | 0.039 | −0.36 | 3.61 | 1.07E-03 | −0.29 | 1.18 | 2.07E-01 |
| chr8:135542653-135582073 | KHDRBS3 | 5.50E-04 | −− | 0.039 | −0.28 | 1.92 | 3.54E-03 | −0.29 | 0.54 | 6.27E-02 |
| chr6:54149055-54189914 | MLIP | 6.03E-04 | −? | 0.042 | −0.35 | 1.66 | 6.03E-04 | NA | NA | NA |
| chr1:83911164-83947282 | TTLL7 | 6.13E-04 | ++ | 0.042 | 0.33 | 2.74 | 4.09E-04 | 0.14 | 1.17 | 4.73E-01 |
| chr1:233198938-233236980 | PCNX2 | 6.42E-04 | −− | 0.042 | −0.26 | 2.34 | 1.42E-03 | −0.21 | 1.05 | 1.95E-01 |
| chr4:118105017-118143684 | NDST3 | 6.48E-04 | −− | 0.042 | −0.25 | 2.25 | 9.12E-03 | −0.44 | 0.97 | 2.07E-02 |
| chr7:43492074-43501322 | HECW1 | 6.86E-04 | −− | 0.043 | −0.33 | 1.09 | 1.55E-04 | −0.04 | 0.14 | 8.27E-01 |
| chr12:44665483-44714741 | NELL2 | 7.12E-04 | −? | 0.043 | −0.32 | 1.29 | 7.12E-04 | NA | NA | NA |
| chr2:30459551-30568176 | LCLAT1 | 7.18E-04 | −− | 0.043 | −0.33 | 0.60 | 6.40E-04 | −0.11 | −0.06 | 4.00E-01 |
| chr16:53254437-53274302 | CHD9 | 7.57E-04 | −− | 0.044 | −0.20 | 1.07 | 3.04E-02 | −0.46 | 0.26 | 2.68E-03 |
| chr7:18666212-18666476 | HDAC9 | 7.78E-04 | −− | 0.045 | −0.29 | 1.09 | 6.00E-04 | −0.10 | −0.21 | 4.44E-01 |
| chr1:98953069-98956741 | PLPPR5 | 8.42E-04 | −− | 0.047 | −0.38 | 1.77 | 3.63E-04 | −0.08 | 0.07 | 6.27E-01 |
| chr7:14672928-14718685 | DGKB | 8.57E-04 | −− | 0.047 | −0.29 | 0.58 | 1.62E-03 | −0.18 | −0.10 | 2.29E-01 |
| chr6:163455278-163478896 | QKI | 8.84E-04 | ++ | 0.048 | 0.22 | 2.92 | 2.23E-02 | 0.61 | 2.36 | 6.79E-03 |
Dir: Direction, Ave Expr: Average Expression, FC: Fold change