FIGURE 1.

Bidirectional Interconnection between microbiota and chemotherapy. The microbiota can through many mechanisms alter and modify the chemotherapy compound by increasing or decreasing its efficacy. At the same time, chemotherapeutic compounds have an effect of alteration of the microbiota, in particular with a decrease in some symbiotic bacterial populations and an increase in potentially pathological ones, with the consequent onset of greater drug toxicity and a higher incidence of concomitant pathologies.