TABLE 2.

Regional effect of hs-CRP concentration on selected ROIs.

ROI	β	SE	95% CI	p	pFDR
L caudal anterior cingulate cortex	−0.024	0.062	−0.147∼0.098	0.693	0.733
L caudal middle frontal gyrus	0.030	0.051	−0.069∼0.129	0.552	0.733
L entorhinal cortex	0.091	0.052	−0.011∼0.192	0.083	0.397
L fusiform	0.158	0.048	0.065∼0.251	0.001	0.023
L isthmus cingulate cortex	0.055	0.050	−0.044∼0.154	0.275	0.710
L parahippocampal gyrus	0.158	0.052	0.057∼0.26	0.002	0.029
L posterior cingulate cortex	−0.019	0.049	−0.116∼0.078	0.700	0.733
L precuneus	0.064	0.043	−0.021∼0.15	0.137	0.547
L rostral anterior cingulate cortex	0.036	0.055	−0.071∼0.143	0.507	0.733
L rostral middle frontal gyrus	0.040	0.040	−0.038∼0.119	0.314	0.710
L supramarginal gyrus	0.043	0.047	−0.048∼0.134	0.355	0.710
R caudal anterior cingulate cortex	0.056	0.056	−0.055∼0.166	0.327	0.710
R caudal middle frontal gyrus	−0.051	0.049	−0.146∼0.045	0.303	0.710
R entorhinal cortex	0.040	0.052	−0.062∼0.142	0.443	0.733
R fusiform	0.058	0.043	−0.027∼0.143	0.177	0.608
R isthmus cingulate cortex	−0.017	0.051	−0.118∼0.083	0.733	0.733
R parahippocampal gyrus	0.108	0.051	0.007∼0.208	0.035	0.211
R posterior cingulate cortex	−0.043	0.051	−0.143∼0.057	0.406	0.733
R precuneus	0.027	0.043	−0.058∼0.112	0.531	0.733
R rostral anterior cingulate cortex	0.020	0.054	−0.086∼0.125	0.712	0.733
R rostral middle frontal gyrus	0.023	0.041	−0.056∼0.103	0.568	0.733
R supramarginal gyrus	0.019	0.049	−0.077∼0.115	0.696	0.733
L Hippocampus	0.099	0.042	0.018∼0.181	0.018	0.142
R Hippocampus	0.016	0.045	−0.073∼0.104	0.727	0.733

Robust linear regression was conducted with CRP concentration as the independent variable and selected ROIs as outcome variables after controlled for age, sex, MMSE-J score, body mass index, drinking habits, and estimate total intracranial volume. ROI: region of interest; R: right; L: left; β: Standardized beta coefficient; 95% CI: 95% confidence interval.