TABLE 2.
General data of the 100 selected articles about the effects of alcohol on the central nervous system.
| R1 | Author/Years | Article title/DOI or URL | Description | Number of citations | ||
|---|---|---|---|---|---|---|
| WoS-CC b (citation density c ) | Scopus | Google scholar | ||||
| 1 | Rice and Barone (2000) | Critical periods of vulnerability for the developing nervous system: Evidence from humans and animal models/10.2307/3454543 | Evaluated the neurodevelopmental impairment associated with alcohol exposure | 1998 (86.87) | 2176 | 3226 |
| 2 | Koob (1992) | Drugs of abuse—anatomy, pharmacology and function of reward pathways/10.1016/0165-6147 (92)90060-J | Evaluated reward and addiction pathways associated with alcohol exposure | 1829 (59.00) | 1907 | 2827 |
| 3 | Dunwiddie and Masino (2001) | The role and regulation of adenosine in the central nervous system/10.1146/annurev.neuro.24.1.31 | Evaluated the neuromodulatory effect of exposure to alcohol | 1176 (53.45) | 1263 | 1835 |
| 4 | Ikonomidou et al. (2000) | Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome/10.1126/ciência.283.5398 | Evaluated fetal alcohol syndrome and apoptotic neurodegeneration associated with ethanol exposure | 1081 (47.00) | 1204 | 1612 |
| 5 | Koob (2008) | A role for brain stress systems in addiction/10.1016/j.neuron. 2008.06.012 | Evaluated reward and addiction pathways associated with alcohol exposure | 692 (46.13) | 754 | 1136 |
| 6 | Horrocks and Yeo (1999) | Health benefits of docosahexaenoic acid (DHA)/10.1006/phrs. 1999.0495 | Evaluated the neurodevelopmental impairment associated with alcohol exposure | 685 (28.54) | 771 | 1389 |
| 7 | Boden and Fergusson (2011) | Alcohol and depression/10.1111/j.1360-0443.2010.03351.x | Evaluated depression associated with exposure to ethanol | 650 (54.17) | 682 | 1164 |
| 8 | Hoyme et al. (2005) | A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: Clarification of the 1996 Institute of Medicine Criteria/10.1542/peds. 2004-0259 | Evaluated clinical approach in diagnosing fetal alcohol spectrum disorders | 642 (35.67) | 731 | 1133 |
| 9 | Fiala et al. (2002) | Dendritic spine pathology: Cause or consequence of neurological disorders?/10.1016/S0165-0173 (02)00158-3 | Evaluated neurological disorders and cognitive deficits associated with exposure to alcohol | 615 (29.29) | 660 | 970 |
| 10 | Chudley et al. (2005) | Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis/10.1503/cmaj.1040302 | Evaluated fetal alcohol syndrome associated with alcohol exposure | 608 (33.78) | 688 | 1198 |
| 11 | Clarren et al. (1997) | Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder/10.1002/(SICI)1096-9926 (199711)56:5 < 317:AID-TERA5>3.0.CO;2-U | Evaluated fetal alcohol syndrome associated with alcohol exposure | 574 (22.08) | 670 | 1126 |
| 12 | Polich and Criado (2006) | Neuropsychology and neuropharmacology of P3a and P3b/10.1016/j.ijpsycho. 2005.12.012 | Evaluated the effect of alcohol on brain potential related to events | 524 (30.82) | 555 | 841 |
| 13 | Nordmann et al. (1992) | Implication of free-radical mechanisms in ethanol-induced cellular injury/10.1016/0891-5849 (92)90030-K | Evaluated oxidative damage associated with alcohol exposure | 520 (16.77) | 556 | 813 |
| 14 | Liou et al. (1997) | Environmental risk factors and Parkinson’s disease: A case-control study in Taiwan/10.1212/WNL.48.6.1583 | Evaluated the risk of Parkinson’s disease associated with exposure to alcohol | 504 (19.38) | 568 | 838 |
| 15 | Courtney and Polich (2009) | Binge drinking in young adults: data, definitions, and determinants/10.1037/a0014414 | Evaluated the epidemiology, definitions and determinants of excessive alcohol consumption in young adults | 476 (34.00) | 495 | 872 |
| 16 | McBride and Li (1998) | Animal models of alcoholism: Neurobiology of high alcohol-drinking behavior in rodents/10.1615/critrevneurobiol.v12.i4.40 | Evaluated neurobiological and behavioral mechanisms associated with the abusive use of ethanol | 476 (19.04) | 502 | 674 |
| 17 | Eckardt et al. (1998) | Effects of moderate alcohol consumption on the central nervous system/10.1111/j.1530-0277.1998.tb03695.x | Evaluated the effects of alcohol consumption on the central nervous system | 472 (18.88) | 510 | 818 |
| 18 | McKinney et al. (2007) | Posterior reversible encephalopathy syndrome: Incidence of atypical regions of involvement and imaging findings/10.2214/AJR.07.2024 | Evaluated clinical manifestations and regions involved in reversible posterior encephalopathy syndrome associated with alcohol consumption | 455 (28.44) | 514 | 802 |
| 19 | Pich et al. (1995) | Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis/10.1523/JNEUROSCI.15-08-05439.1995 | Evaluated the corticotropin-releasing factor in the anxiogenic effects stimulated by ethanol abstinence | 451 (16.11) | 504 | 623 |
| 20 | Crews and Boettiger (2009) | Impulsivity, frontal lobes and risk for addiction/10.1016/j.pbb. 2009.04.018 | Evaluated cortical changes associated with alcohol consumption | 446 (31.86) | 475 | 830 |
| 21 | May and Gossage (2001) | Estimating the prevalence of fetal alcohol syndrome—A summary/https://pubmed.ncbi.nlm.nih.gov/11810953/ | Evaluated the prevalence of fetal alcohol syndrome in the United States | 442 (20.09) | 493 | 888 |
| 22 | Bonthius and West (1990) | Alcohol-induced neuronal loss in developing rats—increased brain-damage with binge exposure/10.1111/j.1530-0277.1990.tb00455.x | Evaluated the lowest daily dose of alcohol capable of inducing neuronal loss, as well as the regions most sensitive to damage | 434 (13.15) | 460 | 630 |
| 23 | Mehta et al. (2013) | Excitotoxicity: Bridge to various triggers in neurodegenerative disorders/10.1016/j.ejphar. 2012.10.032 | Reviewed the role of calcium, mitochondrial dysfunction, reactive oxygen species, nitric oxide, chloride homeostasis, and eicosanoid pathways in the stimulation and maintenance of neuronal excitation | 427 (42.70) | 452 | 663 |
| 24 | Riley et al. (2011) | Fetal Alcohol Spectrum Disorders: An Overview/10.1007/s11065-011-9166-x | Evaluated changes in brain development associated with fetal alcohol syndrome | 422 (35.17) | 456 | 760 |
| 25 | De Bellis et al. (2000) | Hippocampal volume in adolescent-onset alcohol use disorders/10.1176/appi.ajp.157.5.737 | Evaluated the volume of the hippocampus of adolescents and adults with disorders due to alcohol use with those of healthy individuals | 409 (17.78) | 473 | 837 |
| 26 | Fadda and Rossetti (1998) | Chronic ethanol consumption: From neuroadaptation to neurodegeneration/10.1016/S0301-0082 (98)00032-X | Evaluated neurobiological changes induced by alcohol as well as the neuropathological consequences of abuse for cognitive functions and aerial structures | 407 (16.28) | 456 | 699 |
| 27 | Kril et al. (1997) | The cerebral cortex is damaged in chronic alcoholics/10.1016/S0306-4522 (97)00083-3 | Evaluated neurodegeneration of the cerebral cortex of alcoholics | 387 (14.88) | 413 | 617 |
| 28 | Crews and Nixon (2009) | Mechanisms of Neurodegeneration and Regeneration in Alcoholism/10.1093/alcalc/agn079 | Evaluated neuronal death and loss of neurogenesis induced by alcohol, as well as the effects induced by abstinence | 386 (27.57) | 411 | 611 |
| 29 | Grobin et al. (1998) | The role of GABA(A) receptors in the acute and chronic effects of ethanol/10.1007/s002130050685 | Evaluated the interactions of alcohol with GABAA receptors and their association with the acute actions, tolerance, dependence and self-administration of ethanol | 383 (15.32) | 412 | 593 |
| 30 | Crews et al. (2000) | Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats/10.1111/j.1530-0277.2000.tb01973.x | Evaluated the effects and brain damage induced by excessive alcohol consumption | 382 (16.61) | 411 | 629 |
| 31 | Deitrich et al. (1989) | Mechanism of action of ethanol-initial central-nervous-system actions/https://pharmrev.aspetjournals.org/content/41/4/489 | Evaluated the mechanisms of action of alcohol in the central nervous system | 381 (11.21) | 402 | 584 |
| 32 | Moselhy et al. (2001) | Frontal lobe changes in alcoholism: A review of the literature/10.1093/alcalc/36.5.357 | Evaluated the neurophysiological, morphological and neuropsychological effects of alcohol on the central nervous system | 378 (17.18) | 425 | 734 |
| 33 | Alfonso-Loeches et al. (2010) | Pivotal Role of TLR4 Receptors in Alcohol-Induced Neuroinflammation and Brain Damage/10.1523/JNEUROSCI.0976-10.2010 | Evaluated Toll-like receptors in ethanol-induced glial activation, as well as brain damage resulting from this activation | 370 (28.46) | 417 | 552 |
| 34 | Heinz et al. (2000) | A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity/10.1016/S0006-3223 (99)00171-7 | Evaluated the genetic variation of the serotonin transporter (5-HTT) and its association with susceptibility to the neurotoxic effects of chronic excessive alcohol consumption | 366 (15.91) | 410 | 539 |
| 35 | May et al. (2018) | Prevalence of fetal alcohol spectrum disorders in 4 US communities/10.1001/jama. 2017.21896 | Evaluated the prevalence of fetal alcohol spectrum disorders and alcohol-related neurodevelopmental disorders in the US. | 353 (70.60) | 378 | 553 |
| 36 | He and Crews (2008) | Increased MCP-1 and microglia in various regions of the human alcoholic brain/10.1016/j.expneurol. 2007.11.017 | Evaluated microglial activation by pro-inflammatory cytokines and their association with damage induced by alcohol abuse | 352 (23.47) | 380 | 483 |
| 37 | Qin et al. (2008) | Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment/10.1186/1742-2094-5-10 | Evaluated gene expression and protein synthesis of cytokines, oxidative enzymes, microglial activation and inhibition of neurogenesis induced by lipopolysaccharide and whether alcohol abuse potentiates its effects | 347 (23.13) | 397 | 532 |
| 38 | Nixon and Crews (2002) | Binge ethanol exposure decreases neurogenesis in adult rat hippocampus/10.1046/j.1471-4159.2002.01214.x | Evaluated the effect of alcohol exposure on proliferation and survival of neural progenitor cells | 345 (16.43) | 380 | 541 |
| 39 | Sullivan et al. (2000) | Pattern of motor and cognitive deficits in detoxified alcoholic men/10.1111/j.1530-0277.2000.tb02032.x | Evaluated executive functions, visuospatial skills, gait, and balance of individuals detoxified by alcohol for a month with healthy individuals | 332 (14.43) | 361 | 546 |
| 40 | Squeglia et al. (2009) | The influence of substance use on adolescent brain development/10.1177/155005940904000110 | Evaluated studies on neurocognition, brain structure and function in adolescents exposed to alcohol and marijuana | 321 (22.93) | 338 | 669 |
| 41 | Weiss et al. (2006) | Compulsive drug-seeking behavior and relapse—Neuroadaptation, stress, and conditioning factors/10.1111/j.1749-6632.2001.tb03556.x | Evaluated the neuroadaptive changes that oppose the acute reinforcement actions of drugs of abuse, as well as the onset of anxiety, dysphoria, and depression during abstinence | 320 (14.55) | 352 | 525 |
| 42 | Casey et al. (2011) | Braking and accelerating of the adolescent brain/10.1111/j.1532-7795.2010.00712.x | Evaluated the mechanisms involved in increased sensitivity, motivational cues, and cognitive control in adolescence and their association with alcohol and drug abuse | 310 (25.83) | 349 | 692 |
| 43 | Sullivan and Pfefferbaum (2005) | Neurocircuitry in alcoholism: A substrate of disruption and repair/10.1007/s00213-005-2267-6 | Evaluated by neuroimaging the alterations in the structure, physiology, and function of the neural systems induced by excessive alcohol consumption | 310 (17.22) | 345 | 528 |
| 44 | Crews et al. (2006) | Cytokines and alcohol/10.1111/j.1530-0277.2006.00084.x | Evaluated cytokine production in response to alcohol abuse | 307 (18.06) | 330 | 470 |
| 45 | Lewohl et al. (2000) | Gene expression in human alcoholism: Microarray analysis of frontal cortex/10.1111/j.1530-0277.2000.tb01993.x | Evaluated changes in brain gene expression responsible for tolerance, dependence, and neurotoxicity induced by alcohol abuse | 305 (13.26) | 329 | 430 |
| 46 | Kumar et al. (2009) | The role of GABA(A) receptors in the acute and chronic effects of ethanol: A decade of progress/10.1007/s00213-009-1562-z | Evaluated mechanisms of action of ethanol in the nervous system mediated by the GABAA receptor | 303 (21.64) | 335 | 492 |
| 47 | Tsai et al. (1995) | The glutamatergic basis of human alcoholism/10.1176/ajp.152.3.332 | Evaluated the effects of alcohol on glutamatergic transmission and its possible association with alcohol-related problems | 295 (10.54) | 324 | 533 |
| 48 | Hoyme et al. (2016) | Updated clinical guidelines for diagnosing fetal alcohol spectrum disorders/10.1542/peds. 2015-4256 | Guidelines for the management of children with potential fetal alcohol spectrum disorders | 291 (41.57) | 359 | 560 |
| 49 | Chanraud et al. (2007) | Brain morphometry and cognitive performance in detoxified alcohol-dependents with preserved psychosocial functioning/10.1038/sj.npp.1301219 | Evaluated the extent of brain structure damage and cognitive deficits in alcohol-dependent men | 289 (18.06) | 317 | 489 |
| 50 | Grace (2000) | The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving/10.1080/09652140050111690 | Evaluated the tonic versus phasic relationship in the dopaminergic system and its association with dependence, abstinence, and continued desire for drug use | 288 (12.52) | 319 | 512 |
| 51 | Diamond and Gordon (1997) | Cellular and molecular neuroscience of alcoholism/10.1152/physrev. 1997.77.1.1 | Evaluated changes in the transduction of signals activated by neurotransmitter hormones that lead to changes in cell function and gene expression in alcoholism | 287 (11.04) | 316 | 458 |
| 52 | Astley and Clarren (2000) | Diagnosing the full spectrum of fetal alcohol-exposed individuals: Introducing the 4-Digit Diagnostic Code/10.1093/alcalc/35.4.400 | Evaluated a new diagnostic method for fetal alcohol spectrum syndrome and compared it with the gestalt method | 285 (12.39) | 347 | 617 |
| 53 | Harding et al. (2000) | Degeneration of anterior thalamic nuclei differentiates alcoholics with amnesia/10.1093/brain/123.1.141 | Evaluated degeneration of amnesic and non-amnesic alcoholic anterior thalamic nuclei | 281 (12.22) | 322 | 462 |
| 54 | Windle et al. (2008) | Transitions into underage and problem drinking: Developmental processes and mechanisms between 10 and 15 years of age/10.1542/peds. 2007-2243C | Evaluated the impairments in neurodevelopment resulting from exposure to alcohol in the age group of 10–15 years | 279 (18.60) | 291 | 459 |
| 55 | LeMarquand et al. (1994) | Serotonin and alcohol intake, abuse, and dependence—clinical-evidence/10.1016/0006-3223 (94)90630-0 | Evaluated the effects and alterations triggered by alcohol consumption in the serotonergic system, in normal and dependent patients | 279 (9.62) | 208 | 422 |
| 56 | Berman and Hannigan (2000) | Effects of prenatal alcohol exposure on the hippocampus: Spatial behavior, electrophysiology, and neuroanatomy/10.1002/(SICI)1098-1063 (2000)10:1 < 94:AID-HIPO11 > 3.0.CO;2-T | Evaluated the teratogenic effects of prenatal alcohol exposure on the hippocampus | 274 (11.91) | 291 | 416 |
| 57 | Bava and Tapert (2010) | Adolescent brain development and the risk for alcohol and other drug problems/10.1007/s11065-010-9146-6 | Evaluated neurodevelopment in adolescence and the changes and mechanisms involved as a result of alcohol consumption | 272 (20.92) | 300 | 605 |
| 58 | Zeigler et al. (2005) | The neurocognitive effects of alcohol on adolescents and college students/10.1016/j.ypmed. 2004.04.044 | Evaluated neurodevelopment in adolescence and the changes and mechanisms involved as a result of alcohol consumption | 272 (15.11) | 299 | 652 |
| 59 | Harper (1998) | The neuropathology of alcohol-specific brain damage, or does alcohol damage the brain?/10.1097/00005072-199802000-00001 | Evaluated neuropathological changes related to excessive and prolonged alcohol use | 272 (10.88) | 325 | 474 |
| 60 | Roberto et al. (2003) | Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons/10.1073/pnas.0437926100 | Evaluated the ethanol–GABA interaction in the central nucleus of the amygdala and its relationship with the potentiating effects of ethanol | 270 (13.50) | 286 | 400 |
| 61 | Caine et al. (1997) | Operational criteria for the classification of chronic alcoholics: Identification of Wernicke’s encephalopathy/10.1136/jnnp.62.1.51 | Evaluated operational criteria for the diagnosis of Wernicke’s encephalopathy | 270 (10.38) | 307 | 504 |
| 62 | Roberts et al. (1996) | Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats/10.1111/j.1530-0277.1996.tb01125.x | Evaluated a model for evaluating reinforcement-related mechanisms and neurotransmitter pathways involved in alcohol reward | 268 (9.93) | 288 | 335 |
| 63 | Pascual et al. (2007) | Intermittent ethanol exposure induces inflammatory brain damage and causes long-term behavioural alterations in adolescent rats/10.1111/j.1460-9568.2006.05298.x | Evaluated the inflammatory pathways involved in alcohol-induced brain damage | 265 (16.56) | 292 | 414 |
| 64 | VanDoren et al. (2000) | Neuroactive steroid 3 alpha-hydroxy-5 alpha-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol/10.1523/JNEUROSCI.20-05-01982.2000 | Evaluated the association between increased levels of the neurosteroid allopregnanolone and the hypnotic effect of alcohol | 261 (11.35) | 292 | 333 |
| 65 | De Bellis (2002) | Developmental traumatology: A contributory mechanism for alcohol and substance use disorders/10.1016/S0306-4530 (01)00042-7 | Evaluated the association between childhood trauma and increased risk of problems with alcohol and other drug use | 260 (12.38) | 298 | 516 |
| 66 | Goodlett et al. (2005) | Alcohol teratogenesis: Mechanisms of damage and strategies for intervention/10.1177/15353702-0323006-07 | Evaluated the mechanisms involved in the development of the neuroteratogenic effects of alcohol | 259 (14.39) | 293 | 466 |
| 67 | Romero et al. (1998) | Lipid peroxidation products and antioxidants in human disease/10.2307/3433990 | Evaluated the association between increased lipid peroxidation products and their influence on antioxidant levels | 256 (10.24) | 315 | 547 |
| 68 | Fernandez-Lizarbe et al. (2009) | Critical role of TLR4 response in the activation of microglia induced by ethanol/10.4049/jimmunol.0803590 | Evaluated TLR4 receptors in microglial activation induced by alcohol consumption | 254 (18.14) | 282 | 363 |
| 69 | Roberts et al. (2000) | mu-opioid receptor knockout mice do not self-administer alcohol/https://jpet.aspetjournals.org/content/293/3/1002 | Evaluated the effect of μ-opioid receptors on the alcohol reinforcement system and its possible therapeutic target | 252 (10.96) | 271 | 373 |
| 70 | Charness et al. (1989) | Ethanol and the nervous-system/10.1056/NEJM198908173210706 | Evaluated the effects of alcohol on the nervous system and its association with consumption patterns | 251 (7.38) | 279 | 462 |
| 71 | de Fonseca et al. (2005) | The endocannabinoid system: Physiology and pharmacology/10.1093/alcalc/agh110 | Evaluated the application of cannabinoid receptor antagonists as a therapeutic alternative to alcohol addiction | 248 (13.78) | 287 | 503 |
| 72 | Crews et al. (1996) | Effects of ethanol on ion channels/10.1016/s0074-7742 (08)60670-4 | Evaluated the role of ion channels in the mechanisms of alcohol toxicity | 248 (9.19) | 261 | 344 |
| 73 | Hommer et al. (2001) | Evidence for a gender-related effect of alcoholism on brain volumes/10.1176/appi.ajp.158.2.198 | Evaluated sensitivity to alcohol-induced neurotoxicity between genders | 245 (11.14) | 283 | 418 |
| 74 | Thompson et al. (2009) | Prenatal exposure to drugs: Effects on brain development and implications for policy and education/10.1038/nrn2598 | Evaluated neurodevelopmental changes triggered by prenatal alcohol exposure | 243 (17.36) | 264 | 400 |
| 75 | Townshend and Duka (2005) | Binge drinking, cognitive performance and mood in a population of young social drinkers/10.1097/01.ALC.0000156453.05028.F5 | Evaluated the cognitive performance of compulsive drinkers and compared them to non-compulsive drinkers | 243 (13.50) | 256 | 414 |
| 76 | Porjesz et al. (2005) | The utility of neurophysiological markers in the study of alcoholism/10.1016/j.clinph. 2004.12.016 | Evaluated the association between changes in electroneurophysiological markers and predisposition to develop alcohol-related problems | 242 (13.44) | 264 | 338 |
| 77 | Olney et al. (2002) | Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain/10.1016/S0165-3806 (02)00279-1 | Evaluated ethanol-induced apoptotic neurodegeneration in mice during synaptogenesis | 240 (11.43) | 258 | 324 |
| 78 | Medina et al. (2008) | Prefrontal cortex volumes in adolescents with alcohol use disorders: Unique gender effects/10.1111/j.1530-0277.2007.00602.x | Evaluated the association between alcohol abuse in adolescence and reduced volume of the prefrontal cortex | 237 (15.80) | 260 | 387 |
| 79 | Riley et al. (1995) | Abnormalities of the corpus-callosum in children prenatally exposed to alcohol/10.1111/j.1530-0277.1995.tb01600.x | Evaluated the corpus callosum of children exposed to high doses of alcohol in the prenatal period | 237 (8.46) | 279 | 418 |
| 80 | Guerri et al. (2009) | Foetal alcohol spectrum disorders and alterations in brain and behaviour/10.1093/alcalc/agn105 | Evaluated the effects of ethanol on the nervous system and its association with cognitive, behavioral and psychopathological deficits | 236 (16.86) | 261 | 419 |
| 81 | Harper (2009) | The neuropathology of alcohol-related brain damage//10.1093/alcalc/agn102 | Evaluated the human brain image bank to assess changes induced by alcohol abuse | 236 (16.86) | 272 | 459 |
| 82 | Harper and Matsumoto (2005) | Ethanol and brain damage/10.1016/j.coph. 2004.06.011 | Evaluated the mechanisms underlying brain damage induced by alcohol exposure | 236 (13.11) | 278 | 470 |
| 83 | Brower (2003) | Insomnia, alcoholism and relapse/10.1016/S1087-0792 (03)90005-0 | Assessed insomnia in alcohol abstinence and its association with relapse | 236 (11.80) | 273 | 389 |
| 84 | Sayette (1993) | An appraisal-disruption model of alcohols effects on stress responses in social drinkers/10.1037/0033-2909.114.3.459 | Evaluated the effects of alcohol on stress responses among social drinkers | 235 (7.83) | 251 | 455 |
| 85 | Popova et al. (2016) | Comorbidity of fetal alcohol spectrum disorder: a systematic review and meta-analysis/10.1016/S0140-6736 (15)01345-8 | Evaluated the comorbidities associated with fetal alcohol aspect disorder | 234 (33.43) | 260 | 465 |
| 86 | Wozniak et al. (2004) | Apoptotic neuro degeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults/10.1016/j.nbd. 2004.08.006 | Evaluated neuronal apoptotic death of hippocampal circuit structures and its association with reduced spatial memory capacity | 232 (12.21) | 247 | 320 |
| 87 | Mumenthaler et al. (1999) | Gender differences in moderate drinking effects/https://www-ncbi-nlm-nih.ez3.periodicos.capes.gov.br/pmc/articles/PMC6761697/ | Evaluated the difference in the effects of alcohol between genders | 231 (9.63) | 257 | 450 |
| 88 | Harris et al. (1995) | Mutant mice lacking the gamma-isoform of protein-kinase-c show decreased behavioral actions of ethanol and altered function of gamma-aminobutyrate type-a receptors/10.1073/pnas.92.9.3658 | Evaluated calcium/phospholipid-dependent protein kinase and its role in the sensitivity of type A gamma-aminobutyrate receptors to ethanol | 225 (8.04) | 226 | 314 |
| 89 | Martin et al. (2003) | The role of thiamine deficiency in alcoholic brain disease/https://www-ncbi-nlm-nih.ez3.periodicos.capes.gov.br/pmc/articles/PMC6668887/ | Evaluated the nutritional deficiency of thiamine resulting from chronic alcohol consumption and its association with alcohol-induced brain damage | 223 (11.15) | 262 | 469 |
| 90 | Guerri and Pascual (2010) | Mechanisms involved in the neurotoxic, cognitive, and neurobehavioral effects of alcohol consumption during adolescence/10.1016/j.alcohol. 2009.10.003 | Evaluated the mechanism of neurotoxic, cognitive, and neurobehavioral effects induced by alcohol consumption during adolescence | 222 (17.08) | 241 | 430 |
| 91 | Haorah et al. (2008) | Mechanism of alcohol-induced oxidative stress and neuronal injury/10.1016/j.freeradbiomed. 2008.08.030 | Evaluated neurocognitive deficits, neuronal injury, and neurodegeneration associated with the progression of neuroinflammation triggered by oxidative damage to mitochondria and cellular proteins | 222 (14.80) | 257 | 338 |
| 92 | Bookstein et al. (2002) | Corpus callosum shape and neuropsychological deficits in adult males with heavy fetal alcohol exposure/10.1006/nimg. 2001.0977 | Evaluated neuropsychological deficits associated with changes in the shape of the corpus callosum resulting from fetal alcohol exposure | 219 (10.43) | 248 | 362 |
| 93 | Begleiter and Porjesz (1999) | What is inherited in the predisposition toward alcoholism? A proposed model/10.1111/j.1530-0277.1999.tb04269.x | Evaluated the association between predisposition to alcoholism and hereditary hyperexcitability of the nervous system | 215 (8.96) | 228 | 325 |
| 94 | Livy et al. (2003) | Fetal alcohol exposure and temporal vulnerability: Effects of binge-like alcohol exposure on the developing rat hippocampus/10.1016/S0892-0362 (03)00030-8 | Evaluated fetal alcohol exposure and changes in the hippocampus, as well as changes in the learning and memory process | 214 (10.70) | 226 | 312 |
| 95 | Costa et al. (2004) | Developmental neuropathology of environmental agents/10.1146/annurev.pharmtox.44.101802.121424 | Evaluated morphological changes associated with alcohol consumption | 213 (11.21) | 256 | 359 |
| 96 | Olney et al. (2006) | Drug-induced apoptotic neurodegeneration in the developing brain/10.1111/j.1750-3639.2002.tb00467.x | Evaluated the mechanisms of induction of alcohol-induced apoptotic neurodegeneration | 213 (10.24) | 244 | 343 |
| 97 | Nagel et al. (2005) | Reduced hippocampal volume among adolescents with alcohol use disorders without psychiatric comorbidity/10.1016/j.pscychresns. 2005.05.008 | Evaluated the reduction of hippocampal volume in adolescents with alcohol use disorders | 211 (11.72) | 240 | 364 |
| 98 | Maier and West (2001) | Drinking patterns and alcohol-related birth defects/www-ncbi-nlm-nih.ez3.periodicos.capes.gov.br/pmc/articles/PMC6707176/pdf/arcr-25-3-168.pdf | Evaluated fetal alcohol exposure during and its association with cognitive and behavioral deficits | 211 (9.59) | 249 | 440 |
| 99 | Rangaswamy et al. (2002) | Beta power in the EEG of alcoholics/10.1016/S0006-3223 (02)01362-8 | Evaluated the beta potency in the electroencephalogram at rest to assess excitation-inhibition imbalance in the central nervous system of alcoholics | 209 (9.95) | 246 | 395 |
| 100 | Herrera et al. (2003) | Selective impairment of hippocampal neurogenesis by chronic alcoholism: Protective effects of an antioxidant/10.1073/pnas.1230907100 | Evaluated neurogenesis in the adult hippocampus and the impairment associated with oxidative damage induced by alcohol consumption | 204 (10.20) | 219 | 321 |
a
R = rank.
b
WoS-CC, web of science core collection.
c
Citation density = Mean based on the ratio of the number of citations and the period since the year of publication up to December 2022.