Table 2.
Clinical trials listed on clinicaltrials.gov for amyotrophic lateral sclerosis
| No | Disease | Sponsor | Cell type | Route | Cell dose | Planned participants | Year | Phase | Clinical trial # |
|---|---|---|---|---|---|---|---|---|---|
| 1 | ALS | Azienda Ospedaliera Santa Maria, Terni, Italy | Human fetal NSC | Intraspinal | 2.25 or 4.5 M | 18 | 2011 | 1 | NCT01640067 |
| 2 | ALS | Cedars-Sinai Medical Center | Human neural progenitor cells expressing GDNF (CNS10-NPC-GDNF) | Unilateral lumbar spinal cord injections | 0.2 M, 0.5 M | 18 | 2017 | 1 | NCT02943850 |
| 3 | ALS | Kadimastem | ESC-derived astrocyte (AstroRx) | IT | 100 M, 250 M | 16 | 2018 | 1,2 | NCT03482050 |
| 4 | ALS | Q Therapeutics | Glial restricted progenitor cells (Q cell) | Transplantation into lumbar or cervical spinal cord | Lumbar (dose 1), cervical (dose 1,2,3,4,5) | 30 | 2021 | 1,2 | NCT02478450 |
| 5 | ALS | Cedars-Sinai Medical Center | Human neural progenitor cells expressing GDNF (CNS10-NPC-GDNF) | Injection into motor cortex | 5.25M, 10.5M | 16 | 2022 | 1 | NCT05306457 |
| 6 | ALS | Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia | Autologous BMSC | Intraspinal | Not mentioned | 11 | 2007 | 1/2 | NCT00855400 |
| 7 | ALS | Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia | Autologous BMSC | IT | Not mentioned | 63 | 2010 | 1/2 | NCT01254539 |
| 8 | ALS | The First Affiliated Hospital of Dalian Medical University | Autologous peripheral blood MNC | Transplant into subarachnoid space | Not mentioned | 14 | 2010 | na | NCT03085706 |
| 9 | ALS | Mayo Clinic | Autologous adipose MSC | Intraspinal | 1 M | 1 | 2010 | 1 | NCT01142856 |
| 10 | ALS | Mayo Clinic | Autologous adipose MSC | IT | 10, 50, 100 M, 200 M | 27 | 2012 | 1 | NCT01609283 |
| 11 | ALS | Mayo Clinic | Autologous adipose MSC | IT | 60-150M | 60 | 2017 | 2 | NCT03268603 |
| 12 | ALS | Corestem | Autologous BM MSC (HYNR-CS inj) | IT | 2 M/kg | 71 | 2011 | 1,2 | NCT01363401 |
| 13 | ALS | Corestem | Autologous BM MSC [Lenzumestrocel (Neuronata-R Inj.)] | IT | 2 M/kg or 5 M/kg | 115 | 2021 | 3 | NCT04745299 |
| 14 | ALS | Brainstorm-cell therapeutics | Autologous BM MSC secreting neurotrophic factors (MSC-NTF) | IT and IM | IT (24 M), I M (60 M) | 12 | 2011 | 1,2 | NCT01051882 |
| 15 | ALS | Brainstorm-cell therapeutics | autologous BM MSC secreting neurotrophic factors (MSC-NTF) | IM | 94 M, 141 M or 188 M | 14 | 2012 | 2 | NCT01777646 |
| 16 | ALS/ND | Hanyang University Seoul Hospital | Autologous BM MSC (HYNR-CS inj) | IT | 0.5,1 or 2 M/kg | 6 | 2012 | 1 | NCT01758510 |
| 17 | ALS | Bioinova, s.r.o. | Autologous BM MSC | IT | 15 ± 4.5 M cells | 26 | 2012 | 1,2 | NCT03828123 |
| 18 | ALS | Hospital Universitario Dr. Jose E. Gonzalez | Autologous HSC | IT | Not mentioned | 14 | 2012 | 2/3 | NCT01933321 |
| 19 | ALS | Royan Institute | Autologous BM MSC | IV | 2 M/kg | 6 | 2013 | 1 | NCT01759797 |
| 20 | ALS | Royan Institute | Autologous BM MSC | IT | 2 M/kg | 8 | 2013 | 1 | NCT01771640 |
| 21 | ALS | Royan Institute | Allogenic adipose MSC | IV | 2 M/kg | 19 | 2014 | 1 | NCT02492516 |
| 22 | ALS | Brainstorm-cell therapeutics | Autologous BM MSC (NurOwn) | IT and IM | Not mentioned | 48 | 2014 | 2 | NCT02017912 |
| 23 | ALS | Brainstorm-cell therapeutics | Autologous BM MSC(NurOwn) | IT | Not mentioned | 263 | 2017 | 3 | NCT03280056 |
| 24 | ALS | Andalusian initiative for advanced therapies - Fundación Pública Andaluza Progreso y Salud | Autologous adipose MSC | IV | 1,2 or 4 M/kg | 52 | 2014 | 1,2 | NCT02290886 |
| 25 | ALS | China Medical University Hospital | Autologous adipose MSC | IV and intracerebral | IV(200-800 M), IC (100-400 M) | 1 | 2015 | 1 | NCT02383654 |
| 26 | ALS | Hospital e Maternidade Dr. Christóvão da Gama | Autologous MSC | IT | 100 M | 3 | 2015 | 1 | NCT02987413 |
| 27 | ALS | Mossakowski Medical Research Centre Polish Academy of Sciences | Autologous adipose regenerative cells | Intraspinal/IT | 44 M | 30 | 2015 | 1 | NCT03296501 |
| 28 | ALS | Hadassah Medical Organization | Autologous BM MSC | IT | 4 M/kg | 20 | 2016 | 1,2 | NCT04821479 |
| 29 | Stroke/TBI/Parkinson/ALS/ Alzheimer/ Dementia | MD Stem Cells | Autologous BMSC | IV and intranasal | Not mentioned | 500 | 2016 | na | NCT02795052 |
| 30 | ALS | Polski Bank Komorek Macierzystych JSC (PBKM) | WJ MSC | IT | Not mentioned | 20 | 2020 | 1,2 | NCT04651855 |
| 31 | ALS | Rapa Therapeutics LLC | Autologous hybrid TREG/Th2 Cell (RAPA-501) | IV | 20 M or 80 M | 21 | 2020 | 1/2 | NCT04220190 |
| 32 | ALS | Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia | Autologous BM MNC | IM | Not mentioned | 100 | 2021 | 2 | NCT04849065 |
Abbreviations: ALS, amyotrophic lateral aclerosis; BM, bone marrow; GDNF, glial-derived neurotrophic factors; HSC, hemopoietic stem cells; IM, intramuscular; IT, intrathecal; IV, intravenous; M, million; MNC, mononuclear cells; MSC, mesenchymal stem cells; na, not applicable NSC, neural stem cells; SC, stem cells; TBI, traumatic brain injury; UC, umbilical cord; WJ, Wharton Jelly.