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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: Hear Res. 2023 May 26;435:108819. doi: 10.1016/j.heares.2023.108819

Figure 1: Overview of study methodology.

Figure 1:

A: Brief overview of experimental timeline B: Three viral vector constructs carrying fluorescent reported mCLover3 were produced. HdAd5 vector constructs expressing mClover3 under the control of both CAG and CMV promoters were produced as well as an HdAd 5/35 construct expressing mClover3 under control of a CAG promoter. C: Three mouse models were used in our experiments. CBA/CaJ wild type adult mouse was injected with all three viral vector constructs. CD46 transgenic mice on a C57/Bl6 background were injected with HdAd5-CAG-mClover3 and HdAd 5/35-CAG-mClover3 constructs. Neonatal C57/Bl6 mice were injected with HdAd 5-CAG-mCLover3 viral construct. D: Illustration of approaches used to deliver viral vector. Created with Biorender.com