Table 2.

Select human α cell identity markers from single cell RNA-sequencing studies

Gene	Description	Protein class	Human ES	Primate	Pig	Mouse
ARX	Aristaless related homeobox	Homeodomain transcription factor	Exp	ND	*	Exp
CHGA	Chromogranin A	Intercellular signal molecule	Exp	Exp	Exp	Exp
CHGB	Chromogranin B	Intercellular signal molecule	Exp	Exp	Exp	Exp
FOXA2	Forkhead box A2	Winged helix/forkhead transcription factor	Exp	Exp	Exp	Exp
FOXO1	Forkhead box O1	Winged helix/forkhead transcription factor	ND	Exp	Exp	Exp
GATA6	GATA binding protein 6	DNA-binding transcription factor	ND	ND	Exp	Exp
ISL1	ISL LIM homeobox 1	Homeodomain transcription factor	Exp	Exp	Exp	Exp
MAFB	MAF bZIP transcription factor B	Basic leucine zipper transcription factor	Exp	ND	ND	Exp
NEUROD1	Neuronal differentiation 1	Basic helix-loop-helix transcription factor	Exp	Exp	Exp	Exp
NKX2–2	NK2 homeobox 2	Homeodomain transcription factor	ND	Exp	Exp	Exp
PAX6	Paired box 6	Homeodomain transcription factor	Exp	Exp	Exp	Exp
POU6F2	POU class 6 homeobox 2	DNA-binding transcription factor	ND	ND	Exp	Exp
PTPRT	Protein tyrosine phosphatase receptor type T	Protein phosphatase	ND	ND	*	Exp
RFX6	Regulatory factor X6	Winged helix/forkhead transcription factor	Exp	Exp	Exp	Exp
SCG5	Secretogranin V	Intercellular signal molecule	Exp	Exp	Exp	Exp
SLC38A4	Solute carrier family 38 member 4	Amino acid transporter	Exp	Exp	Exp	Exp
WNT4	Wnt family member 4	Intercellular signal molecule	Exp	Exp	Exp	Exp