Table 1.

Cohort information overview.

Cohort	RUN DMC	SCANS	HARMONISATION
Baseline Cohort Size	503	121	265
Inclusion Criteria	Symptomatic SVD, defined as the presence of lacunes or WMH on neuroimaging, and accompanying acute (lacunar stroke) or subacute (cognitive, motor) symptoms. Aged 50–85.	Symptomatic SVD, defined as a clinical lacunar stroke syndrome with MRI evidence of an anatomically corresponding lacunar infarct and confluent regions of WMH graded ≥ 2 on the modified Fazekas scale [18].	Combination of: • Patients with cognitive impairment but no dementia, defined as being impaired in at least one cognitive domain on a neuropsychological test battery without loss of daily functions. • Controls with no cognitive impairment on neuropsychological tests, or function loss, but may had subjective complaints of memory impairment.
Centres	Department of Neurology, Radboud University Nijmegen, The Netherlands	Stroke service at 3 hospitals in South London, UK	Memory clinics at National University Hospital and Saint Luke's Hospital, and adjacent community in Singapore
Recruitment Period	2006	12.2007–08.2010	08.2010–12.2016
Follow-up Period	Until 2015; 9 years.	Until 08.2015; 5 years.	Until 09.2020; 5 years.
Assessments	MRI and neuropsychological tests at baseline, year 5 and 9.	MRI at baseline, year 1,2,3. Neuropsychological tests at baseline, year 1,2,3,4,5.	MRI and neuropsychological tests at baseline, year 2,5.
Dementia Diagnosis	DSM-IV	DSM-V	DSM-IV

SVD = Cerebral small vessel disease; WMH= White matter hyperintensity; MRI = Magnetic resonance imaging; DSM = Diagnostic and Statistical Manual of Mental Disorders.