Table 2.
Cohort characteristics.
| Cohort | RUN DMC | SCANS | HARMONISATION | POOLED |
|---|---|---|---|---|
| Sample size in survival analysis | 439 | 110 | 240 | 789 |
| No. dementia cases in survival analysis | 50 (11.4%) | 19 (17.3%) | 39 (16.2%) | 108 (13.7%) |
| Cases per dementia subtype in survival analysis | 28 AD 14 VD 6 mixed AD/VD 1 LBD 1 Unknown |
19 VD | 34 AD 5 VD |
62 AD 38 VD 6 mixed AD/VD 1 LBD 1 Unknown |
| Follow-up years Median (IQR) | 8.7 (8.5, 8.9) | 5.0 (4.0, 5.1) | 4.0 (3.0, 5.0) | 5.4 (4.1, 8.7) |
| Sample size in classification analysis | 429 | 98 | 223 | 750 |
| No. dementia cases (by year 3) in classification analysis | 14 (3.3%) | 10 (10.2%) | 24 (10.8%) | 48 (6.4%) |
| Cases per dementia subtype in classification analysis | 11 AD 2 VD 1 Unknown |
10 VD | 22 AD 2 VD |
33 AD 14 VD 1 Unknown |
| Input Features* | ||||
| Age Mean (SD) | 65.17 (8.87) | 70.01 (9.93) | 70.98 (7.61) | 67.62 (9.10) |
| Years of Education Mean (SD) | 10.88 (3.55) | 11.56 (3.49) | 8.45 (4.90) | 10.24 (4.18) |
| Sex (Female%) | 196 (44.6%) | 39 (35.5%) | 130 (54.2%) | 365 (46.3%) |
| Hypertension (Yes%) | 317 (72.2%) | 101 (91.8%) | 159 (66.2%) | 577 (73.1%) |
| Hypercholesterolaemia (Yes%) | 194 (44.2%) | 95 (86.4%) | 185 (77.1%) | 474 (60.1%) |
| Diabetes mellitus (Yes%) | 52 (11.8%) | 21 (19.1%) | 71 (29.6%) | 144 (18.3%) |
| Smoking (Yes%) | 307 (69.9%) | 67 (60.9%) | 53 (22.1%) | 427 (54.1%) |
| White matter lesion load Median (IQR) | 0.29 (0.10, 0.98) | 3.06 (1.60, 4.54) | 0.24 (0.05, 0.81) | 0.37 (0.11, 1.42) |
| Lacune count Median (IQR) | 0 (0, 0) | 2 (0, 5) | 0 (0, 1) | 0 (0, 1) |
| Presence of cerebral microbleeds (Yes%) | 69 (15.7%) | 43 (39.1%) | 89 (37.1%) | 201 (25.5%) |
| Total brain volume (ml) Mean (SD) | 1069.13 (77.22) | 1043.10 (104.14) | 896.86 (96.40) | 1013.10 (116.78) |
| PSMD Mean (SD) | 3.46 × 10−4 (7.55 × 10−5) | 3.77 × 10−4 (1.11 × 10−4) | 3.40 × 10−4 (7.31 × 10−5) | 3.49 × 10−4 (8.16 × 10−5) |
| Global cognition Mean (SD) | 0.03 (0.73) | −0.65 (0.81) | −0.56 (0.82) | −0.25 (0.83) |
| Executive function Mean (SD) | 0.02 (0.76) | −0.86 (1.05) | −0.68 (1.45) | −0.32 (1.12) |
| Processing speed Mean (SD) | 0.04 (0.85) | −0.99 (0.88) | −0.51 (1.05) | −0.27 (1.00) |
AD = Alzheimer's dementia; VD = Vascular dementia; LBD = Lewy body dementia; IQR = Interquartile range (25%, 75%); SD = Standard deviation; PSMD = Peak width of skeletonised mean diffusivity.
⁎
Statistics of the input features are for the sample included in the survival analysis.