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. 2023 Aug 5;65:102831. doi: 10.1016/j.redox.2023.102831

Fig. 6.

Fig. 6

GPx1 expression in glioblastoma patients is associated with HIF-1α expression, poor outcomes, the expression of HIF-1α target genes, and exosome markers. (A and B) Immunohistochemical staining of GPx1 in human low-grade and high-grade glioma samples. T means tumor whereas N represents normal brain tissues. (C and D) Immunohistochemical scores of GPx1 expression in brain glioma tissue arrays. (E) Kaplan-Meier analyses of the overall survival rate of 32 glioblastoma patients relative to GPx1 expression. GPx1 expression in glioblastoma samples was determined by immunohistochemical staining. (F) Immunofluorescence imaging of GPx1 and HIF‐1α expression in human glioblastoma specimens. (G) Gene associations between GPx1 and HIF‐1α in 12 human glioblastoma samples. (H) Survival curves comparing patients with high (blue) and low (red) GPx1 expression in glioma using the REMBRANDT dataset. (I) Box plots comparing GPx1 expression in various grades of glioma using the REMBRANDT dataset. (J–O) Gene correlation of GPx1/HIF1A, GPx1/EPAS1, GPx1/HK2, GPx1/LDHA, GPx1/CD63 or GPx1/CD81 in glioma using the REMBRANDT dataset. Error bars, SD within triplicate experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 compared to corresponding groups. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)