FIG. 1.

Dose-dependent protection after i.n. immunization with tl EDIM. Groups of mice were immunized and challenged as described in the legend to Table 1. Stools collected for the 7 days following challenge were quantified for rotavirus shedding by an ELISA. Shedding was compared to that found in mock-immunized control mice. ∗, P < 0.001 versus mock-immunized mice; ∗∗, P = 0.002 versus mock-immunized mice.