FIG. 2.

Protection against EDIM shedding after i.n. immunization with homotypic and heterotypic dl and tl rotavirus particles. Mice immunized as stated in the legend of Table 1 were challenged with 4 × 10⁴ infectious EDIM, and stool samples collected for the 7 days after challenge were quantified for rotavirus antigen. All particles provided significant (P < 0.001) protection from shedding relative to mock-immunized control mice. Significant (P ≤ 0.01) increases in shedding between groups relative to mice immunized with tl EDIM, are indicated by an asterisk.