TABLE 2.

Geometric mean titers (GMTs) of rotavirus antibodies stimulated by i.n. immunization with tl or dl particles of homotypic and heterotypic rotaviruses^a

Immunogen	GMT
	Serum		Stool (IgA)
	IgG	IgA
None	<100	<100	<5
tl EDIM	49,900	1,970	78
dl EDIM	59,400	2,300	155
tl RRV	83,900	2,020	72
dl RRV	37,000	1,130	84
tl WC3	78,200	1,780	37
dl WC3	64,100	2,830	349b
tl 89-12	29,600	940	69
dl 89-12	13,900	1,080	71

^aGroups of eight BALB/c mice immunized with two doses of 10 μg (separated by 2 weeks) of tl or dl rotavirus particles. Rotavirus antibody titers were determined in serum and stool specimens collected 4 weeks after the last immunization (i.e., 1 day before EDIM challenge). 

^bSignificantly (P < 0.001) greater than that stimulated by tl WC3.