TABLE 3.

Effect of LT(192G) on rotavirus antibody responses after i.n. immunization with tl or dl particles^a

Immunogen	GMT of rotavirus antibodies
	Serum IgG			Serum IgA			Stool IgA
	+LT	−LT	+LT/−LT	+LT	−LT	+LT/−LT	+LT	−LT	+LT/−LT
tl EDIM	31,606	288	110b	590	113	5.2b	35	6	5.8b
dl EDIM	345,918	92,292	3.7b	3,673	3,108	1.2	561	280	2.0
tl RRV	150,315	74,027	2.0b	2,290	1,497	1.5	158	148	1.1
dl RRV	209,530	36,551	5.7b	1,668	1,131	1.5	265	84	3.6
tl WC3	244,196	78,215	3.1b	2,191	1,776	1.2	382	37	10.3b
dl WC3	212,488	64,119	3.3b	3,835	2,831	1.4	398	349	1.1
tl 89-12	60,146	29,633	2.0	1,212	942	1.3	58	69	0.8
dl 89-12	92,753	13,940	6.7b	2,116	1,084	2.0	255	71	3.6b

^aGroups of eight BALB/c mice were given two i.n. immunizations with 10 μg/dose of each particle except for tl EDIM at 0.25 μg/dose. Titers were determined 4 weeks after the second immunization. GMT, geometric mean titer. 

^bSignificant (P ≤ 0.004) increases due to the inclusion of LT(R192G).