TABLE 4.
Effect of LT(R192G) during i.n. immunization on rotavirus shedding after challengea
| Immunogen | Rotavirus shedding (% antigen shed vs mock-immunized mice)
|
Pb | |
|---|---|---|---|
| −LT(R192G) | +LT(R192G) | ||
| tl EDIMc | 67.0 | 2.7 | <0.001 |
| dl EDIM | 4.8 | 0.6 | NS |
| tl RRV | 11.5 | 1.5 | 0.003 |
| dl RRV | 55.3 | 1.1 | <0.001 |
| tl WC3 | 13.1 | 2.1 | 0.01 |
| dl WC3 | 4.1 | 1.1 | 0.01 |
| tl 89-12 | 30.0 | 0.0 | NS |
| dl 89-12 | 24.4 | 6.1 | NS |
a
Mice immunized as described in the legend to Table 3 were challenged 4 weeks after the second immunization with EDIM, and the shedding of rotavirus antigen was determined by ELISA during the subsequent 7 days.
b
Significance of difference between mice immunized with or without LT(R192G). NS, not significant.
c
Groups administered tl EDIM were immunized with 0.25 μg/dose, while other groups were given 10 μg/dose.