. 1999 Sep;73(9):7565–7573. doi: 10.1128/jvi.73.9.7565-7573.1999

TABLE 6.

Protection after oral versus i.n. immunization with or without LT(R192G)^a

Immunogen	LT	Rotavirus shedding (% antigen shed vs. mock-immunized mice)		P^b
Immunogen	LT	i.n.	Oral	P^b
tl EDIM	−	0.0^c	6.6^c	<0.001
tl EDIM	+	0.0^c	0.0^c ^d	NS
dl EDIM	−	4.8^c	39.4^c	<0.001
dl EDIM	+	0.6^c	1.7^c ^d	NS
tl RRV	−	11.5^c	85.1	<0.001
tl RRV	+	1.5^c	14.6^c ^d	NS

Groups of eight BALB/c mice were given two oral (gavage) or i.n. immunizations (10 μg/dose) either without or with LT(R192G) (10 μg) and challenged with EDIM 4 weeks after the last dose. Shedding of rotavirus antigen was determined by ELISA during the subsequent 7 days.

Significance of difference between orally and i.n. immunized mice. NS, not significant.

Significantly (P < 0.001) less shedding than in mock-immunized mice.

Significantly (P ≤ 0.003) less shedding than in mice orally immunized without LT(R192G).