TABLE 7.

Comparative protection induced by 10-fold lower doses of dl EDIM and tl RRV during i.n. immunization^a

Immunogen	LT	Rotavirus shedding (% antigen shed vs mock-immunized mice) at:		Pb
		10 μg/dose	1 μg/dose
dl EDIM	−	4.8	31.9	<0.001
dl EDIM	+	0.6	2.5	NS
tl RRV	−	11.4	65.5	<0.001
tl RRV	+	1.5	5.5	NS

^aGroups of eight BALB/c mice were given two i.n. doses of either 1 or 10 μg/dose and challenged 4 weeks after the second dose with EDIM. Shedding of rotavirus antigen was measured during the following 7 days. 

^bSignificance of differences between mice given 1 or 10 μg/dose. NS, not significant.