TABLE 8.
Ratios of serum rotavirus IgG1/IgG2a stimulated by different rotavirus particles either with or without LT(R192G)a
| Immunogen | LT(R192G) | GMT of IgG subclasses (μg/ml)
|
||
|---|---|---|---|---|
| IgG1 | IgG2a | IgG1/IgG2ab | ||
| tl EDIM | − | 16.8 | 32.8 | 0.51 |
| dl EDIM | − | 25.8 | 45.1 | 0.57 |
| dl EDIM | + | 315.5 | 269.8 | 1.17 |
| tl RRV | − | 97.5 | 40.5 | 2.41 |
| tl RRV | + | 242.1 | 120.8 | 2.00 |
| tl WC3 | − | 46.6 | 106.4 | 0.44 |
| tl WC3 | + | 297.6 | 330.1 | 0.90 |
| tl 89-12 | − | 9.4 | 47.5 | 0.20 |
| tl 89-12 | + | 64.8 | 57.0 | 1.14 |
a
Mice (eight animals/group) were immunized i.n. with two doses of 10 μg/dose. Rotavirus IgG subclasses in serum were measured at 4 weeks after the second immunization. GMT, geometric mean titer.
b
Ratio of GMTs for the IgG subclasses.