Table 3.
Cases diagnosed as localized malignant mesothelioma by International Mesothelioma Panel members (n=72)
| Contributing Institution | Case No. | Age (yrs.) | Gender | Asbestos exposure | Location of primary lesion | Pleural thickening | Pleural plaque | Effusion | Size (cm) | Histologic subtype | Treatment | Recurrence | Follow-up |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Royal Brompton and Harefield | 1 | 95 | F | No | Chest wall, right | NA | NA | NA | 7 | Sarcomatoid, desmoplastic | Chest wall resection | No | Alive @ 14 days |
| National Health Hospitals | 2 | 74 | M | NA | Mediastinum, left | No | No | No | 5.4 | Pleomorphic | NA | NA | Dead @ 3 months |
| London, U.K. | 3 | 72 | M | NA | Chest wall, right | No | Yes | No | 12.1 | Epithelioid | NA | No | Dead @ 12 months |
| (n = 16) | 4 | 44 | M | NA | Pleura, right | No | No | No | 4.8 | Epithelioid | NA | No | Dead @ 24 months |
| 5 | 63 | M | Yes, NOS | Pleura, right | Yes | Yes | NA | 5.5 | Epithelioid | Pleurectomy, decortication, chemo | Yes localized @ 91 mos | Alive@134 months | |
| 6 | 78 | F | NA | Chest wall, right | No | No | No | 7.9 | Sarcomatoid, desmoplastic | Active surveillance | No | Dead @ 65 months | |
| 7 | 70 | M | Yes, NOS | Pleura, right | No | No | No | 2 | Epithelioid | Lobectomy | No | Dead @ 74 months | |
| 8 | 71 | F | NA | Pleura, right | No | No | No | 4.5 | Epithelioid | Chest wall resection | No | Alive @ 72 months | |
| 9 | 76 | M | NA | Chest wall, right | No | No | No | 4.5 | Sarcomatoid | Chest wall resection | No | Alive @ 58 months | |
| 10 | 77 | M | NA | Chest wall, right | Yes | No | No | 8.5 | Sarcomatoid | Chest wall resection | No | Dead @ 10 months | |
| 11 | 63 | M | No | RUL Lung, right | NA | NA | NA | 1.2 | Biphasic, osteosarcomatous | Wedge resection | No | Alive @ 16 months | |
| 12 | 60 | F | No | Chest wall, right | No | No | Yes | 12.5 | Biphasic | Chest wall resection | No | Dead @ 3 months | |
| 13 | 82 | M | No | Chest wall, right | No | No | Yes | 11.6 | Biphasic, desmoplastic | Neoadjuvant chemoradiation, chest wall resection | Yes @ 15.1 mos | Dead @ 30 months | |
| 14 | 66 | M | Yes, NOS | Pleura, right | NA | Yes | NA | 7.5 | Biphasic | Chest wall resection | No | Alive @ 26 months | |
| 15 | 68 | F | NA | Mediastinum, right | No | No | No | 5.2 | Biphasic | NA | No | Alive @ 2 days | |
| 16 | 65 | F | NA | Right lower lobe, lung | No | No | Yes | 6.3 | Epithelioid | Lobectomy | No | Alive @ 9 months | |
| Duke University | 17 | 78 | M | Yes, Navy | Pleura, right | N | N | Y | 2 | Epithelioid | Wedge resection | NA | NA |
| Durham, North Carolina | 18 | 55 | F | Yes, Household, exposure friction products | Fallopian tube, right | N | N | N | NA | Epithelioid | Colectomy, BSO**, chemo | NA | NA |
| (n = 9) | 19 | 77 | M | Yes, Merchant marine | Pleura, left | N | Y | N | 2 c | Epithelioid | NA | No | Alive @ 120 months |
| 20 | 63 | M | Yes, Shipyard, construction | Posterior mediastinum/ pleura left | N | N | N | 3.1 | Epithelioid | NA | NA | NA | |
| 21 | 60 | M | Yes, Electrician, pipe insulator | Lung, LUL | N | N | N | 8 | Epithelioid | Wedge resection | NA | NA | |
| 22 | 83 | M | Yes, Plumber/pipe fitter, powerplant | Pleura, right | N | N | Y | 3.3 | Epithelioid | NA | Progression @ 5mos | Alive @ 5 months | |
| 23 | 51 | M | Yes, Household, exposure friction products | Pleura, RLL | N | N | Y | 14 | Biphasic, chondrosarcomatous | Pneumonectomy, chemo | No | Alive @ 45 months | |
| 24 | 44 | M | Yes, Friction exposure products | Chest wall NOS | N | Y | N | 5.8 | Epithelioid | Chest wall resection | No | Alive @ 3 months | |
| 25 | 79 | M | No | Chest wall, right 2nd to 3rd ribs | N | Y | N | 3.2 | Epithelioid | Surgical resection | NA | NA | |
| Cedars-Sinai | 26 | 33 | F | No | Pleural based mass Left | N | N | N | 4 | Sarcomatoid | Surgical resection | NA | NA |
| Medical Center | 27 | 80 | M | No | Chest wall, left | N | N | N | 4.7 | Epithelioid | Surgical resection | NA | NA |
| Los Angeles, California | 28 | 74 | M | No | Chest wall, left | N | N | N | 7.7 | Epithelioid | Chemo | Yes @ 132 mos | Alive @ 132 months |
| (n = 8) | 29 | 65 | M | Yes, US Navy, shipyard 4 years | Chest wall, left upper | N | N | N | 5.6 | Sarcomatoid | Surgical resection, chemo | NA | NA |
| 30 | 44 | F | No, teacher | “Ovarian” mass, Right | N | N | N | 3 | Epithelioid | Surgical resection | No | Alive @ 72 months | |
| 31 | 73 | F | No, bank clerk | Chest wall, left upper | N | N | N | 4.5 | Biphasic | Surgical resection | No | Alive @ 24 months | |
| 32 | 87 | M | Yes, merchant marine, gasket worker | Chest, right upper | N | N | N | 2 | Epithelioid | Surgical resection | NA | NA | |
| 33 | 50 | M | Yes, Navy exposure | Chest, right upper | N | N | N | Pleomorphic | Surgical resection | No | Alive @ 36 months | ||
| Mayo Clinic | 34 | 54 | F | No | Hemidiaphragm, left | N | N | N | 6 | Sarcomatoid | Surgical resection, chemo | No | Alive @ 156 months |
| Rochester, Minnesota | 35 | 73 | M | Possible, telephone installer | Chest wall, lung, LUL | N | N | N | 6.5 | Desmoplastic | Surgical resection | Yes @ 8 mos | Dead @ 13 months |
| (n = 7) | 36 | 40 | F | NA | Abdominal wall | Y | N | Y | 19 | Epithelioid | Surgical resection, chemo | Yes @ 5 mos | Alive @ 60 months |
| 37 | 77 | M | Yes, Bystander, shipyard | Testis, spermatic cord | N | N | N | 9 | Epithelioid | Surgical resection | No | Alive @ 36 months | |
| 38 | 56 | F | No | Pleura/lung, RUL | N | N | Y | 5 | Biphasic | Surgical resection, chemo | Yes @ 3 mos | Dead @ 12 months | |
| 39 | 84 | F | NA | Lung, LLL | N | N | N | 3 | Sarcomatoid | Surgical resection radiation | NA | Dead @ 2 months | |
| 40 | 58 | F | NA | Peritoneum, right perihepatic | N | N | Y | 11.7 | Biphasic | Surgical resection, chemo radiation | No | Alive @ 18 months | |
| Mayo Clinic | 41 | 78 | M | NA | Visceral pleura, LUL apex | No | No | NA | 1.8 | Epithelioid | Surgical resection | NA | Alive @ 39 months |
| Scottsdale, Arizona | 42 | 70 | F | NA | Medial LUL | No | No | NA | 3.6 | Epithelioid | Surgical resection | No | Died, 16 days |
| (n = 7) | 43 | 71 | F | NA | Abdominal wall, left upper quadrant | No | No | No | 1.7 | Epithelioid | Surgical resection | No | Alive, @ 98 months |
| 44 | 76 | M | NA | Pleura,RLL | No | NA | NA | 4 | Epithelioid | Surgical resection | Chest recurrences 2 and 3 years, neck met 3 years | Alive @ 36 months | |
| 45 | 77 | F | NA | Pleura,LUL | No | NA | NA | 8 | Epithelioid | Surgical resection | NA | NA | |
| 46 | 63 | M | NA | Left chest wall | No | No | NA | NA | Epithelioid | Surgical resection | NA | NA | |
| 47 | 60 | M | NA | Posterolateral chest wall, laterality NA | No | No | NA | 4.5 | Biphasic | Surgical resection | NA | NA | |
| MESOPATH | 48 | 78 | F | Yes, Bystander, boiler | Parietal pleura NOS | Y | Y | Y | Sarcomatoid | Surgical resection, chemo | Progression @ 4 mos | Alive @ 4 months | |
| Lyon, France | 49 | 59 | F | NA | Chest wall, Left, 2nd~3rd ribs | Y, nodular | Y | Y | 1.5 | Sarcomatoid | Surgical resection | NA | NA |
| (n = 6) | 50 | 65 | M | NA | Pleuropulmonary NOS | N | N | Y | 3.5 | Sarcomatoid | Surgical resection, radiation | Yes, bone met @ 23 mos | NA |
| 51 | 77 | M | NA | Parietal pleura NOS | N | N | N | 6.5 | Epithelioid | Surgical resection, radiation | No | Alive @ 7 months | |
| 52 | 73 | F | NA | Pleura, Pericardium, Diaphragm and Peritoneum | Y | N | N | 5 | Biphasic | Surgical resection | NA | NA | |
| 53 | 59 | F | NA | Pleura, costophrenic angle | N | N | N | Epithelioid | NA | NA | NA | ||
| Brigham and Women’s Hospital Boston, Massachusetts | 54 | 76 | M | Yes, NOS | Pleura and chest wall, RU | Yes (trace thickening near the mass on imaging) | N | N | 13.5 | Biphasic | Neoadjuvant chemo, Surgical resection | Yes | Alive with local recurrence on imaging at 20 months |
| (n = 6) | 55 | 73 | M | Yes, NOS | Pleura and chest wall, RU | N | N | N | 6.0 | Biphasic | Neoadjuvant chemo, Surgical resection | No | Brain metastasis at 11 months; died of disease at 12 months |
| 56 | 53 | F | No | Pleura, LL | N | N | N | 3.4 | Biphasic | Surgical resection | No | Alive with no evidence of disease at 1.4 months | |
| 57 | 28 | F | No | Pleura, LU | N | N | N | 3.9 | Epithelioid | Surgical resection | No | Alive with no evidence of disease at 6 months | |
| 58 | 73 | F | No | Pleura, LL | N | N | Yes (trace) | 2.7 | Biphasic | Surgical resection | NA | NA | |
| 59 | 46 | M | No | Pleura, LL | Indeterminate (“possible left pleural thickening” on imaging) | Yes | N | 8.5 | Epithelioid | Surgical resection | No | Alive with no evidence of disease at 102 months | |
| Flinders | 60 | 80 | M | NA | Pleura, RUL | Y | N | N | 4 | Sarcomatoid | NA | NA | NA |
| University | 61 | 36 | F | Possible, Bystander,home remodel | Mediastinal pleura | N | N | N | 3 | Epithelioid | Surgical resection | Yes @ 84 mos | Died @ 134 months |
| Adelaide, Australia | 62 | 43 | F | NA | Fallopian tube, left | N | N | N | 3.4 | Epithelioid | Surgical resection | No | Alive @ 12 months |
| 63 | 63 | M | NOS occupational exposure | Chest wall, right | Y | N | N | 10 | Sarcomatoid | Surgical resection | No | Alive @ 14 months | |
| 64 | 47 | F | Possible, bystander, home remodel | Broad ligament | N | N | N | 10 | Epithelioid | Surgical resection | No | Alive @ 14 months | |
| 65 | 67 | F | Teacher, possible bystander exposure | Serosa of stomach | N | N | N | 9.5 | Biphasic | Surgical resection | Yes @ 7 mos | Died @ 13 months | |
| University Health Network | 66 | 58 | M | No | Chest wall, RU | N | N | N | 4.8 | Epithelioid, microcystic | Surgical resection, radiation | No | Alive @ 93 months |
| Toronto, Canada | 67 | 46 | M | NA | Paraspinal mass, Left | N | N | N | 5 | Epithelioid | Surgical resection, radiation | No | Alive @ 24 months |
| (n = 3) | 68 | 56 | M | NA | Pleural nodule, left intercostal | N | N | N | 2.8 | Epithelioid, rhabdoid | Surgical resection, chemo preop radiation | No | Alive @ 48 months |
| Massachusetts General Hospital (n = 2) Boston, Massachusetts | 69 | 83 | M | Yes, NOS | Pleura and chest wall, LU | Yes | N | Yes (trace) | 4.2 | Biphasic | Surgical resection, adjuvant chemo | Yes @ 11 mos | Died of disease @ 11 months (with autopsy showing local recurrence of a solitary 13.0-cm mass, along with a 15.0-cm extraperi cardial mass near heart apex and multiple mediastinal nodal metastasis. No other pleural masses.) |
| 70 | 62 | M | No | Pleura and chest wall, RU | Yes (linear thickening near RML on imaging) | N | N | 12.6 | Sarcomatoid | Neoadjuvant chemo/radiation, surgical resection | No | Alive with no evidence of disease @ 75 months | |
| 71 | 54 | F | Chest wall, left pleura | N | N | Y | 4.8 | Epithelioid | NA | NA | |||
| The Mount Sinai Hospital (n = 1) New York, New York | Yes, NOS exposure in 80’s | Induction chemo, Surgical resection, post op radiation | |||||||||||
| Memorial Sloan Kettering Cancer Center (n = 1) New York, New York | 72 | 43 | M | NA | Lung, LUL | NA | NA | NA | 8 | Biphasic | Wedge resection | NA | NA |
NA not available, BSO bilateral salpingo-oophorectomy, NOS not otherwise described