Summary of findings 3. Anticoagulant compared to antiplatelet agent for non‐hospitalised people with COVID‐19.
| Anticoagulant versus antiplatelet agent for non‐hospitalised people with COVID‐19 | ||||||
| Patient or population: non‐hospitalised people with COVID‐19 Setting: outpatient setting Intervention: anticoagulant Comparison: antiplatelet agent | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Risk with antiplatelet agents (short term) | Risk with anticoagulant | |||||
|
All‐cause mortality Follow‐up: 45 days |
Study population | Not estimable | 279 (1 RCT) | ⊕⊕⊕⊝ Moderate a | There were no cases of mortality. | |
| ‐ | ||||||
|
Venous thromboembolism Follow‐up: 45 days |
Study population | RR 0.36 (0.01 to 8.65) | 279 (1 RCT) | ⊕⊕⊝⊝ Low b | ||
| 7 per 1000 | 2 per 1000 (0 to 60) | |||||
|
Major bleeding Follow‐up: 45 days |
Study population | Not estimable | 279 (1 RCT) | ⊕⊕⊕⊝ Moderate a | There were no cases of major bleeding. | |
| ‐ | ||||||
| Deep vein thrombosis | This outcome was not measured. | |||||
| Pulmonary embolism | This outcome was not measured. | |||||
|
Need for hospitalisation Follow‐up: 45 days |
Study population | RR 3.20 (0.13 to 77.85) | 279 (1 RCT) | ⊕⊕⊝⊝ Low b | ||
| 0 out of 144 | 1 out of 135 | |||||
|
Adverse events (minor bleeding) Follow‐up: 45 days |
Study population | RR 2.13 (0.40 to 11.46) |
279 (1 RCT) | ⊕⊕⊝⊝ Low b | ||
| 14 per 1000 | 30 per 1000 (6 to 159) |
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| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RCT: randomised controlled trial; RR: risk ratio | ||||||
| GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. | ||||||
aDowngraded one level due to imprecision (fewer than 300 events included in the analysis). bDowngraded two levels due to imprecision (fewer than 300 events included in the analysis and very wide CI).