Source	Search strategy	Hits retrieved
1. Medline (Ovid MEDLINE® Epub Ahead of Print, In‐Process & Other Non‐Indexed Citations, Ovid MEDLINE® Daily and Ovid MEDLINE®) 1946 to present (Date of most recent search: 18 April 2022)	1 exp COVID‐19/ 2 COVID‐19.ti,ab. 3 COVID19.ti,ab. 4 2019 novel coronavirus infection.ti,ab. 5 coronavirus disease 19.ti,ab. 6 2019 novel coronavirus disease.ti,ab. 7 coronavirus disease 2019.ti,ab. 8 exp Coronavirus/ 9 Coronavirus*.ti,ab. 10 Deltacoronavirus*.ti,ab. 11 Delta‐coronavirus*.ti,ab. 12 or/1‐11 13 exp Anticoagulants/ 14 (anticoagul* or anti‐coagu*).ti,ab. 15 exp Heparin/ 16 heparin*.ti,ab. 17 UFH.ti,ab. 18 LMWH.ti,ab. 19 LMH.ti,ab. 20 (Ariven or Arteven or Calcilean or Hepalean or Hepathrom or Leparan or Lipo‐Hepin or Liquaemin or Liquemin or Pabyrin or Pularin or Thromboliquine or Vetren).ti,ab. 21 (Clexane or klexane or lovenox).ti,ab. 22 Fragmin.ti,ab. 23 Innohep.ti,ab. 24 clivarin*.ti,ab. 25 (danaproid or danaparoid).ti,ab. 26 antixarin.ti,ab. 27 (Zibor or cy 222 or embolex or monoembolex).ti,ab. 28 (rd 11885 or RD1185).ti,ab. 29 (Kabi‐2165 or Kabi 2165).ti,ab. 30 (emt‐966 or emt966 or emt‐967 or emt977 or pk‐10169 or pk10169).ti,ab. 31 (fr‐860 or fr860 or cy‐216 or cy216).ti,ab. 32 (kb101 or lomoparan or orgaran).ti,ab. 33 (fluxum or lohepa or lowhepa).ti,ab. 34 (op 2123 or op2123).ti,ab. 35 (ave 5026 or ave5026).ti,ab. 36 (M118 or RO‐1).ti,ab. 37 coumar*.ti,ab. 38 (warfarin or (vitamin adj3 antagonist*)).ti,ab. 39 (VKA or coumadin* or phenindione or Sinthrome or nicoumalone or phenprocoumon or Marcumar or Falithrom or AVK or phenprocoumon* or aldocumar or carfin or jantoven or kumatox or lawarin or marevan or prothromadin or sofarin or tedicumar or tintorane or waran or warfant or warfilone or warnerin).ti,ab. 40 exp Antithrombins/ 41 exp Hirudin Therapy/ 42 (thrombin adj3 inhib*).ti,ab. 43 hirudin*.ti,ab. 44 (dabigatran or Pradaxa or Rendix).ti,ab. 45 (BIBR‐953* or BIBR953* or BIBR‐1048 or BIBR1048).ti,ab. 46 (ximelagatran or Exanta or Exarta or melagatran).ti,ab. 47 (AZD0837 or AZD‐0837).ti,ab. 48 (S35972 or S‐35972).ti,ab. 49 Factor Xa Inhibitors/ 50 Xarelto.ti,ab. 51 (Bay‐597939 or Bay597939).ti,ab. 52 PRT054021.ti,ab. 53 (BMS‐562247 or BMS‐562247 or ELIQUIS).ti,ab. 54 (DU‐176b or DU176b).ti,ab. 55 (PRT‐054021 or PRT054021).ti,ab. 56 (YM150 or YM‐150 or LY517717 or LY‐517717 or DU‐176b or DU176*).ti,ab. 57 (GW813893 or "Tak 442" or TAK442 or PD0348292 or GSK‐813893 or GSK813893).ti,ab. 58 etexilate.ti,ab. 59 agatroban.ti,ab. 60 or/13‐59 61 12 and 60	April 2022: 3892
2. EMBASE via Ovid (Date of most recent search: 18 April 2022)	1 exp COVID‐19/ 2 COVID‐19.ti,ab. 3 COVID19.ti,ab. 4 2019 novel coronavirus infection.ti,ab. 5 coronavirus disease 19.ti,ab. 6 2019 novel coronavirus disease.ti,ab. 7 coronavirus disease 2019.ti,ab. 8 exp Coronavirus/ 9 Coronavirus*.ti,ab. 10 Deltacoronavirus*.ti,ab. 11 Delta‐coronavirus*.ti,ab. 12 or/1‐11 13 Anticoagulants/ 14 (anticoagul* or anti‐coagu*).ti,ab. 15 exp Heparin/ 16 heparin*.ti,ab. 17 UFH.ti,ab. 18 LMWH.ti,ab. 19 LMH.ti,ab. 20 (Ariven or Arteven or Calcilean or Hepalean or Hepathrom or Leparan or Lipo‐Hepin or Liquaemin or Liquemin or Pabyrin or Pularin or Thromboliquine or Vetren).ti,ab. 21 (Clexane or klexane or lovenox).ti,ab. 22 Fragmin.ti,ab. 23 Innohep.ti,ab. 24 clivarin*.ti,ab. 25 (danaproid or danaparoid).ti,ab. 26 antixarin.ti,ab. 27 (Zibor or cy 222 or embolex or monoembolex).ti,ab. 28 (rd 11885 or RD1185).ti,ab. 29 (Kabi‐2165 or Kabi 2165).ti,ab. 30 (emt‐966 or emt966 or emt‐967 or emt977 or pk‐10169 or pk10169).ti,ab. 31 (fr‐860 or fr860 or cy‐216 or cy216).ti,ab. 32 (kb101 or lomoparan or orgaran).ti,ab. 33 (fluxum or lohepa or lowhepa).ti,ab. 34 (op 2123 or op2123).ti,ab. 35 (ave 5026 or ave5026).ti,ab. 36 (M118 or RO‐1).ti,ab. 37 coumar*.ti,ab. 38 (warfarin or (vitamin adj2 antagonist*)).ti,ab. 39 (VKA or coumadin* or phenindione or Sinthrome or nicoumalone or phenprocoumon or Marcumar or Falithrom or AVK or phenprocoumon* or aldocumar or carfin or jantoven or kumatox or lawarin or marevan or prothromadin or sofarin or tedicumar or tintorane or waran or warfant or warfilone or warnerin).ti,ab. 40 exp Antithrombins/ 41 exp Hirudin Therapy/ 42 (thrombin adj3 inhib*).ti,ab. 43 hirudin*.ti,ab. 44 (dabigatran or Pradaxa or Rendix).ti,ab. 45 (BIBR‐953* or BIBR953* or BIBR‐1048 or BIBR1048).ti,ab. 46 (ximelagatran or Exanta or Exarta or melagatran).ti,ab. 47 (AZD0837 or AZD‐0837).ti,ab. 48 (S35972 or S‐35972).ti,ab. 49 Factor Xa Inhibitors/ 50 Xarelto.ti,ab. 51 (Bay‐597939 or Bay597939).ti,ab. 52 PRT054021.ti,ab. 53 (BMS‐562247 or BMS‐562247 or ELIQUIS).ti,ab. 54 (DU‐176b or DU176b).ti,ab. 55 (PRT‐054021 or PRT054021).ti,ab. 56 (YM150 or YM‐150 or LY517717 or LY‐517717 or DU‐176b or DU176*).ti,ab. 57 (GW813893 or "Tak 442" or TAK442 or PD0348292 or GSK‐813893 or GSK813893).ti,ab. 58 etexilate.ti,ab. 59 agatroban.ti,ab. 60 or/13‐59 61 12 and 60	April 2022: 7555
3. CINAHL via Ebsco (Date of most recent search: 18 April 2022)	S40 S13 AND S39 S39 S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 OR S22 OR S23 OR S24 OR S25 OR S26 OR S27 OR S28 OR S29 OR S30 OR S31 OR S32 OR S33 OR S34 OR S35 OR S36 OR S37 OR S38 S38 TX agatroban S37 TX etexilate S36 TX Xarelto S35 TX Factor Xa Inhibitor* S34 TX dabigatran or Pradaxa or Rendix S33 TX hirudin* S32 TX thrombin inhib* S31 TX Antithrombins S30 TX VKA or coumadin* or phenindione or Sinthrome or nicoumalone or phenprocoumon or Marcumar or Falithrom or AVK or phenprocoumon* or aldocumar or carfin or jantoven or kumatox or lawarin or marevan or prothromadin or sofarin or tedicumar or tintorane or waran or warfant or warfilone or warnerin S29 TX vitamin K antagonist* S28 TX warfarin S27 TX coumar* S26 TX danaproid or danaparoid S25 TX clivarin* S24 TX Innohep S23 TX Fragmin S22 TX Clexane or klexane or lovenox S21 TX Ariven or Arteven or Calcilean or Hepalean or Hepathrom or Leparan or Lipo‐Hepin or Liquaemin or Liquemin or Pabyrin or Pularin or Thromboliquine or Vetren S20 TX LMH S19 TX LMWH S18 TX UFH S17 TX heparin* S16 (MH "Heparin+") S15 TX anticoagul* or anti‐coagu* S14 (MH "Anticoagulants+") S13 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 OR S9 OR S10 OR S11 OR S12 S12 TX Delta‐coronavirus*. S11 TX Deltacoronavirus* S10 TX Coronavirus* S9 (MH "Coronavirus+") S8 (MH "SARS‐CoV‐2") S7 TX coronavirus disease 2019 S6 TX 2019 novel coronavirus disease S5 TX coronavirus disease 19 S4 TX 2019 novel coronavirus infection S3 TX COVID19 S2 TX COVID‐19 S1 (MH "COVID‐19")	April 2022: 725
4. VASCULAR REGISTER IN CRSW (Date of most recent search: 18 April 2022)	#1 COVID‐19 OR COVID19 OR 2019 novel coronavirus infection OR coronavirus disease 19 OR 2019 novel coronavirus disease OR coronavirus disease 2019 OR Coronavirus* OR Deltacoronavirus* OR Delta‐coronavirus* AND INREGISTER	April 2022: 45
5. CENTRAL via CRSO (Date of most recent search: 18 April 2022)	#1 MESH DESCRIPTOR COVID‐19 EXPLODE ALL TREES 1004 #2 COVID‐19:TI,AB,KY 8293 #3 COVID19:TI,AB,KY 408 #4 (2019 novel coronavirus infection):TI,AB,KY 3 #5 (coronavirus disease 19):TI,AB,KY 49 #6 (2019 novel coronavirus disease):TI,AB,KY 4 #7 (coronavirus disease ):TI,AB,KY 3060 #8 MESH DESCRIPTOR Coronavirus EXPLODE ALL TREES 616 #9 Coronavirus*:TI,AB,KY 5137 #10 Deltacoronavirus*:TI,AB,KY 1 #11 Deltacoronavirus*:TI,AB,KY 1 #12 Delta‐coronavirus*:TI,AB,KY 0 #13 #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 8923 #14 MESH DESCRIPTOR Anticoagulants EXPLODE ALL TREES 11803 #15 (anticoagul* or anti‐coagu*):TI,AB,KY 14242 #16 MESH DESCRIPTOR Heparin EXPLODE ALL TREES 4863 #17 heparin*:TI,AB,KY 12316 #18 UFH:TI,AB,KY 751 #19 LMWH:TI,AB,KY 1453 #20 LMH:TI,AB,KY 9 #21 (Ariven or Arteven or Calcilean or Hepalean or Hepathrom or Leparan or Lipo‐Hepin or Liquaemin or Liquemin or Pabyrin or Pularin or Thromboliquine or Vetren):TI,AB,KY 14 #22 (Clexane or klexane or lovenox):TI,AB,KY 177 #23 Fragmin:TI,AB,KY 224 #24 Innohep:TI,AB,KY 37 #25 clivarin*:TI,AB,KY 22 #26 (danaproid or danaparoid):TI,AB,KY 54 #27 antixarin:TI,AB,KY 2 #28 (Zibor or cy 222 or embolex or monoembolex):TI,AB,KY 38 #29 (fluxum or lohepa or lowhepa):TI,AB,KY 15 #30 coumar*:TI,AB,KY 389 #31 warfarin:TI,AB,KY 4906 #32 (vitamin k antagonist*):TI,AB,KY 1064 #33 (VKA or coumadin* or phenindione or Sinthrome or nicoumalone or phenprocoumon or Marcumar or Falithrom or AVK or phenprocoumon* or aldocumar or carfin or jantoven or kumatox or lawarin or marevan or prothromadin or sofarin or tedicumar or tintorane or waran or warfant or warfilone or warnerin):TI,AB,KY 945 #34 MESH DESCRIPTOR Antithrombins EXPLODE ALL TREES 2289 #35 MESH DESCRIPTOR Hirudin Therapy EXPLODE ALL TREES 75 #36 (thrombin inhib*):TI,AB,KY 546 #37 hirudin*:TI,AB,KY 483 #38 (dabigatran or Pradaxa or Rendix):TI,AB,KY 1068 #39 (ximelagatran or Exanta or Exarta or melagatran):TI,AB,KY 182 #40 MESH DESCRIPTOR Factor Xa Inhibitors EXPLODE ALL TREES 1091 #41 Xarelto:TI,AB,KY 85 #42 etexilate:TI,AB,KY 327 #43 agatroban:TI,AB,KY 2 #44 #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25 OR #26 OR #27 OR #28 OR #29 OR #30 OR #31 OR #32 OR #33 OR #34 OR #35 OR #36 OR #37 OR #38 OR #39 OR #40 OR #41 OR #42 OR #43 28554 #45 #13 AND #44 279	April 2022: 279
6. Clinicaltrials.gov (Date of most recent search: 18 April 2022)	COVID‐19 OR COVID19 OR 2019 novel coronavirus infection OR coronavirus disease 19 OR 2019 novel coronavirus disease OR coronavirus disease 2019 OR Coronavirus* OR Deltacoronavirus* OR Delta‐coronavirus* | Anticoagulants* OR Heparin OR LMWH OR warfarin OR Factor Xa Inhibitors OR Antithrombins OR coumarin	April 2022: 117
7. ICTRP Search Portal (Date of most recent search: 18 April 2022)	COVID‐19 OR COVID19 OR 2019 novel coronavirus infection OR coronavirus disease 19 OR 2019 novel coronavirus disease OR coronavirus disease 2019 OR Coronavirus* OR Deltacoronavirus* OR Delta‐coronavirus* | Anticoagulants* OR Heparin OR LMWH OR warfarin OR Factor Xa Inhibitors OR Antithrombins OR coumarin	April 2022: 80
8. LILACS (Date of most recent search: 18 April 2022)	COVID‐19 OR COVID19 OR Coronavirus OR Deltacoronavirus OR Delta‐coronavirus [Palavras] and Anticoagulants OR Heparin OR LMWH OR warfarin OR Factor Xa Inhibitors OR Antithrombins OR coumarin [Palavras]	April 2022: 75
9. COVID Cochrane Register (Date of most recent search: 18 April 2022)		April 2022: 2571
TOTAL before de‐duplication		April 2022: 15339
TOTAL after de‐duplication		April 2022: 9347