TABLE 5.

Association of TP53 R249M, TP53 R249S, and CTNNB1 S45P mutation with Smoking, BCLC staging and mortality.

	TP53 R249M		TP53 R249S		CTNNB1S45P
Smoking	Yes/No	OR (95%CI); p-value	Yes/No	OR (95%CI); p-value	Yes/No	OR (95%CI); p-value
Smoker	12/4	11.77 (3.219–36.20) p < 0.0001	2/14	0.8730 (0.1737–4.282)	3/13	0.5897 (0.1645–2.298) p = 0.54
Non-Smoker	13/51		9/55	p > 0.99	18/46

	TP53 R249M		TP53 R249S		CTNNB1S45P
BCLC Staging	Yes/No	OR(95%CI); p-value	Yes/No	OR(95%CI); p-value	Yes/No	OR(95%CI); p-value
0+A+B	15/27	1.556 (0.6110–3.8) p = 0.4701	7/35	1.7	8/34	0.6588 (0.2156–1.823) p = 0.5928
C+D	10/28		4/34	0.4639–5.533, p = 0.5246	10/28

	TP53 R249M and R249S		TP53 R249M and R249S and CTNNB1S45P
BCLC Staging	Yes/No	OR(95%CI); p-value	Yes/No	OR(95%CI); p-value
0+A+B	20/22	1.558, (0.6189–3.686), p = 0.3713	25/17	0.9591, (0.4111–2.293),P=>0.9999
C+D	14/24		23/15

	TP53 R249M		TP53 R249S		CTNNB1S45P
Mortality	Yes/No	OR(95%CI); p-value	Yes/No	OR(95%CI); p-value	Yes/No	OR(95%CI); p-value
Dead	15/41	0.5122, (0.1949–0.330), p = 0.2005	9/47	2.106, (0.4622–10.30) p = 0.4904	15/41	1.098,0.3923–3.429 p > 0.9999
Alive	10/14		2/22		6/18