TABLE 2.
MCMV replication in BALB/c mice immunized with low doses of ΔM83 and challenged i.p. with two LD50s of MCMV K181a
| Immunizing ΔM83 dose (PFU) | No. of MCMV-positive organs and MCMV titer in:
|
|||
|---|---|---|---|---|
| Spleen
|
Salivary glands
|
|||
| No. of MCMV-positive organs/total | MCMV titerb | No. of MCMV-positive organs/total | MCMV titer(s) | |
| 30 | 0/4 | <2c | 2/4 | 3.3, 3.8 |
| 200 | 1/4 | 3.7 | 0/4 | <2 |
a
Naive BALB/c female mice were injected i.p. with tissue culture-derived ΔM83 and were challenged i.p. with 5 × 105 PFU of salivary gland-derived K181 at 4 weeks postimmunization. Spleens and salivary glands were harvested at days 6 and 10, respectively, postchallenge.
b
Log PFU of MCMV-positive organ(s).
c
<2, no virus detected.