Abstract Topic: 19. Aggressive Non-Hodgkin lymphoma - Clinical
Background: The occurrence of multiple primary malignant tumors (MPMT) is known to be present in some instances of non-Hodgkin’s lymphoma (NHL).
Aims: Our current study examines the frequency of MPMT in NHL patients in Armenia, including their clinical features and overall patient survival rates.
Methods: The data of 2026 patients with NHL were analyzed. The patients were diagnosed between January 2010 and December 2021 at Hematology Center after Prof. R. Yeolyan of Armenia
Results: Out of the 24 patients diagnosed with MPMT, 19 had synchronous MPMT (sMPMTs), and 5 had metachronous MPMT (mMPMTs). The majority (70%) of patients with MPMT were male, aged >50 years. The most common types of lymphoma among patients with MPMT were diffuse large B-cell lymphoma (DLBCL) and T-cell non-Hodgkin’s lymphoma (T-NHL). Some patients with MPMT had multiple hematological diagnoses, such as T-NHL and Hodgkin’s lymphoma, or DLBCL with myelofibrosis. Solid cancer’s most commonly affected sites were the organs of the gastrointestinal tract (33%) and the mammary gland (33%). The study found that patients with synchronous MPMT had higher overall survival rates than those with metachronous MPMT. However, compared to patients without MPMT, the prognosis for NHL patients with MPMT was slightly worse, with a 5-year overall survival rate of 68.9% and 76.1% (P = 0.042), respectively. Among patients with adenocarcinoma, the cumulative mortality rate from solid tumors was significantly higher in patients with MPMT than in patients without MPMT. The treatment sequence was chosen based on the severity of NHL and solid tumor։ which required immediate chemotherapy.
Summary/Conclusion: When evaluating patients before treatment, it is essential always to consider the possibility of the existence of MPMT. Managing patients with MPMT and NHL, a rare disease, requires a clear protocol and an individualized approach to therapy.
Keywords: Diffuse large B cell lymphoma, Survival, NHL