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Template dependency of RNA synthesis by the wild-type and mutant NS5B. (A) In vitro RdRp assays were conducted by using full-length HCV RNA as a template under the conditions indicated above the gel. + and − indicate the presence and absence, respectively, of the template and NS5B in the RdRp reactions. An arrowhead indicates the position of the template on 1% agarose gel. (B) Enzyme activity of wild-type (NS5B) and mutant (NS5BD318H) NS5B by using the full-length HCV RNA as a template.
