Table 4.

Globule size, polydispersity index and zeta potential of fenofibrate-loaded HME solid self-emulsifying delivery systems (HME S-SEDDS) prepared by Central composite design.

Formulation Code*	Run	Compritol® HD5 ATO (%w/w, ${\text{X}}_1$)	Surfactant: Co-surfactant (${\text{X}}_2$)	Surfactant (%w/w)	Co-surfactant (%w/w)	GS (nm, ${\text{Y}}_1$)	PDI (${\text{Y}}_2$)	ZP (mV, ${\text{Y}}_3$)
F1	1	50.0	1	25.0	25.0	378	0.49	−24.3
F2	2	37.5	0.585786	23.1	39.4	341	0.44	−20.5
F3	3	37.5	2	41.67	20.83	324.5	0.40	−31.1
F4	4	37.5	2	41.67	20.83	329.5	0.41	−29.6
F5	5	25	3	56.25	18.75	265	0.29	−24.2
F6	6	37.5	2	41.67	20.83	319	0.39	−30.8
F7	7	37.5	2	41.67	20.83	320	0.40	–32.0
F8	8	37.5	2	41.67	20.83	324	0.39	−30.4
F9	9	25	1	37.5	37.5	272	0.33	−25.6
F10	10	37.5	3.41421	48.3	14.2	293.6	0.36	–33.8
F11	11	50	3	37.5	12.5	370	0.45	−19.9
F12	12	19.82	2	53.45	26.73	250	0.25	−20.5
F13	13	55.2	2	29.9	14.9	386	0.52	−16.7

GS – globule size, PDI – poly dispersity index, ZP – Zeta potential.

^*All formulations contain fenofibrate (4 % w/w) which is equivalent to 40 mg of dose.