Table 5.

Statistical results of central composite design for optimization of dependent variables and independent variable effects on fenofibrate-loaded HME solid self-emulsifying delivery systems (HME S-SEDDS).

Source	Globule size (${\text{Y}}_1$, nm)				Polydispersity index (${\text{Y}}_2$)				Zeta potential (${\text{Y}}_3$, mV)
	Sum of squares	Degree of freedom	F-value	P-value	Sum of squares	Degree of freedom	F-value	P-value	Sum of squares	Degree of freedom	F-value	P-value
Model	21176.13	3	120.75	<0.0001	0.0662	3	156.10	<0.0001	346.28	5	38.11	<0.0001
${\text{X}}_1$	20334.69	1	347.86	<0.0001	0.0616	1	435.33	<0.0001	122.15	1	67.22	<0.0001
${\text{X}}_2$	841.19	1	14.39	0.0043	0.0047	1	32.97	0.0003	122.53	1	67.43	<0.0001
${\text{X}}_1$ ${\text{X}}_2$	0.2500	1	0.0043	0.9493	0.0000	1	0.0000	1.0000	12.72	7	1.00	0.3499
${\text{X}}_1^2$	―	―	―	―	―	―	―	―	91.22	1	91.22	50.20
${\text{X}}_2^2$	―	―	―	―	―	―	―	―	17.17	1	17.17	9.45
Residuals	526.11	9	―	―	0.0013	9	―	―	9.59	3	―	―
Lack of Fit	456.41	5	5.24	0.0669	0.0010	5	2.84	0.1671	3.13	4	4.09	0.1036
Pure Error	69.70	4	―	―	0.0003	4	―	―	12.72	7	―	―
Total	21702.25	12	―	―	0.0675	12	―	―	9.59	3	―	―
Adjusted ${\text{R}}^2$	0.9677				0.9749				0.9393
Predicted ${\text{R}}^2$	0.9214				0.9456				0.7964
Adequate precision	33.6234				37.6141				17.5503