Table 6.

Summary of dissolution parameters of API and optimized HME S-SEDDS (mean ± SD; n = 6).

Formulation	${\text{Q}}_{15(\%)}$	${\text{Q}}_{60(\%)}$	${\text{DE}}_{15}$	${\text{DE}}_{60}$	IDR	MDR	${\text{t}}_{90\%}$ (minutes)
Fenofibrate (pure API)	8.18 ± 0.181	8.445 ± 0.011	4.09	7.29	0.545	0.165	15
Optimized formulation	90.08 ± 0.13	99.15 ± 0.09	45.04	84.69	6.005	1.850	N/A

${\text{Q}}_{15}$ and ${\text{Q}}_{60}$ - drug released in 15 and 60 min; ${\text{DE}}_{15}$ and ${\text{DE}}_{60}$ are dissolution efficiency at 15 and 60 min; IDR and MDR are the initial dissolution rate at 15 min and mean dissolution rate respectively: ${\text{t}}_{90\%}$ is time at which 90% drug release is achieved.