TABLE 2.

Average pairwise distance values between dUTPases from various groups of organisms

Taxon	Avg pairwise distancea (SD) of:
	HSAPb [1]	ORFV [1]	Poxvirusc [5]	AVAD [1]	PBCV [1]	Eubacteriad [15]	Archaeae [2]
HSAP [1]	0.00 (0.00)
Rodentsf [2]	4.53 (0.68)
Mammalsg [3]		34.50 (0.68)	37.63 (5.68)	34.48 (1.62)	58.99 (1.55)	101.95 (11.52)	194.22 (33.27)
Eukaryotesh [6]	46.65 (6.91)	59.14 (7.93)	67.74 (5.30)	54.86 (6.21)	56.47 (9.04)	97.98 (10.62)	196.66 (24.60)

^aDistance values were calculated as described in Materials and Methods and used to produce the phylogeny reported in Fig. 4. The number of organisms is given in brackets. dUTPase abbreviations are as defined in the text. Standard deviations are in parentheses. 

^bHuman dUTPase (HSAP) is provided as a reference point for comparison with dUTPases from rodents and nonmammalian eukaryotes. 

^cPoxvirus dUTPases excluding that of ORF virus (VACW, VARI, CPOX, VACL, and SPOX). 

^dAll 15 eubacterial sequences as listed in Table 1. 

^eArchaeal dUTPases (MJAN and DAMB). 

^fRodent dUTPases (MMUS and RNOR). 

^gMammalian dUTPases (HSAP, MMUS, and RNOR). 

^hEukaryote dUTPases excluding those of mammals (CELEA, CELEM, CELEC, LESC, CALB, and SCER).