Dual-functional antimicrobial peptides possessing antibacterial and immunomodulatory properties.

Peptide	Sequence	MIC (μM)	Immunomodulatory activity	Ref.
Papiliocin	RWKIFKKIEKVGRNVRDGIIKAGPAVAVVGQAATVVK–NH2	0.58	Lowers NO, TNF-α, MIP-1, MIP-2, IL-1β, IL-6, TLR4, and NF-κB	69
Cathelicidin-PY	KCNFLCKLKEKLRTVITSHIDKVLRPQG	1.37–10.95	Lowers NO, TNF-α, MIP-1, IL-6, TLR4, and NF-κB	70
KR-12-a3	KRIVKRIKKWLR–NH2	2.8	Lowers TNF-α	74
Fowl-1 (8–26)-WRK	LVIRWVRAGYKLYRAIKKK–NH2	3.7	Lowers TNF-α and NO	76
CR-163	RRWVQRWIRRWRKWV	5	Lowers NO, TNF-α, IL-6, and IL-8	82 and 83
A7	ILKWKWKWWKWRR–NH2	7.5	Lowers NO	84
MC1-1	SAVGRHGRRFGLRKHRKH	3.59–4.42	Lowers TNF-α and IL-6	87
TL-3	FVRWWSRWLRRIL–NH2	5.7	Lowers TNF-α and NO	89
K6L2W3	KLWKKWKKWLK–NH2	1–2	Lowers NO	95
KLW-f	KWKKLLKKfLKLfKKLLK–NH2a	0.5–2	Lowers NO	97
D-RR4	wlrrikawlrrika–NH2b	2–8	Lowers TNF-α and IL-6	100
Lf-KR	RRWQWRPKRIVKLIKKWLR–NH2	7	Lowers TNF-α and NO	103
PapMa-k	RWKIFKKIkKFLHSAKKF–NH2c	2–8	Lowers TNF-α, IL-1β, MIP-1, and MIP-2	104

^af symbolizes phenylalanine peptoid.

^bSmaller case letters represent d-amino acids.

^ck symbolizes lysine peptoid.