Inhibition of dynamin I lipid-stimulated GTPase activity (IC50a (μM)) by analogues 16, 19 and 24–26.
| Compound | Structure | Dynamin I IC50a (μM) |
|---|---|---|
| 16 |
|
38.2 ± 6.0 |
| 19 |
|
7.0 ± 0.8 |
| 24 |
|
96.8 ± 13.1 |
| 25 |
|
30.1 ± 9.7 |
| 26 |
|
>300b |
IC50 and 95% CI of triplicates, n = 1;
Less than 50% inhibition at 300 μM drug concentration.