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. 2023 Apr 26;14(8):1492–1511. doi: 10.1039/d2md00371f

Inhibition of dynamin I lipid-stimulated GTPase activity (IC50a (μM)) by analogues 16, 19 and 24–26.

Compound Structure Dynamin I IC50a (μM)
16 graphic file with name d2md00371f-u3.jpg 38.2 ± 6.0
19 graphic file with name d2md00371f-u4.jpg 7.0 ± 0.8
24 graphic file with name d2md00371f-u5.jpg 96.8 ± 13.1
25 graphic file with name d2md00371f-u6.jpg 30.1 ± 9.7
26 graphic file with name d2md00371f-u7.jpg >300b
a

IC50 and 95% CI of triplicates, n = 1;

b

Less than 50% inhibition at 300 μM drug concentration.