Inhibition of dynamin I lipid-stimulated GTPase activity (IC50a (μM)) by analogues 16, 19 and 24–26.
Compound | Structure | Dynamin I IC50a (μM) |
---|---|---|
16 | 38.2 ± 6.0 | |
19 | 7.0 ± 0.8 | |
24 | 96.8 ± 13.1 | |
25 | 30.1 ± 9.7 | |
26 | >300b |
IC50 and 95% CI of triplicates, n = 1;
Less than 50% inhibition at 300 μM drug concentration.