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. 2023 Apr 26;14(8):1492–1511. doi: 10.1039/d2md00371f

Inhibition of dynamin I lipid-stimulated GTPase activity (IC50a (μM)) by analogues 19, and 31–34.

graphic file with name d2md00371f-u8.jpg
Compound R Dynamin I IC50a (μM)
19 graphic file with name d2md00371f-u9.jpg 7.0 ± 0.8
31 graphic file with name d2md00371f-u10.jpg 7.1 ± 1.1
32 graphic file with name d2md00371f-u11.jpg 8.1 ± 1.1
33 graphic file with name d2md00371f-u12.jpg 3.7 ± 1.7b
34 graphic file with name d2md00371f-u13.jpg 58.2 ± 8.6
a

IC50 and 95% CI of triplicates, n = 1;

b

Mean and SEM of 3 independent experiments each performed in triplicate.