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. 2023 Apr 26;14(8):1492–1511. doi: 10.1039/d2md00371f

Inhibition of dynamin I lipid—stimulated GTPase activity (IC50a (μM)) by analogues 19 and 39–42.

graphic file with name d2md00371f-u14.jpg
Compound R Dynamin I IC50a (μM)
19 graphic file with name d2md00371f-u15.jpg 7.0 ± 0.8
39 graphic file with name d2md00371f-u16.jpg 9.5 ± 1.8
40 graphic file with name d2md00371f-u17.jpg 3.9 ± 0.4
41 graphic file with name d2md00371f-u18.jpg 4.4 ± 0.4
42 graphic file with name d2md00371f-u19.jpg 3.6 ± 0.7
a

IC50 and 95% CI of triplicates, n = 1.