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Cell surface HSPGs mediate the uptake of ApoE. (A) ApoE-containing lipoproteins are taken up by LRP1 in an HSPG dependent mechanism. (B) The HS disaccharide repeats is composed of glucuronic/iduronic acid followed by N-acetylglucosamine. HS sulfotransferases act upon GlcNAc at N-acetyl, 3-O, and 6-O sites and uronic acid at the 2-O site, producing distinct patterns of sulfation. (C) Structure of AD enriched HS glycan tetra-1.
