Table 1.
Patient Baseline Characteristics
| Patient Data | Control (n=14) | HFpEF (n=16) | p value |
|---|---|---|---|
| Age (years) | 68 ± 12 | 66 ± 7 | 0.70 |
| Female (%) | 29 | 25 | 0.83 |
| Heart Rate (bpm) | 67 ± 11 | 72 ± 10 | 0.28 |
| BMI (kg/m2) | 30 ± 5 | 37 ± 6 | 0.002 |
| BSA (m2) | 2.0 ± 0.2 | 2.2 ± 0.3 | 0.01 |
| SBP (mmHg) | 123 ± 12 | 138 ± 11 | 0.002 |
| DBP (mmHg) | 75 ± 9 | 73 ± 20 | 0.68 |
| Creatinine (mg/dL) | 0.87 ± 0.19 | 1.03±0.19 | 0.19 |
| NT-proBNP (pg/ml)* | 155 (89–328) | 1554 (888–2178) | <0.001 |
| LVEDP (mmHg) | 13 ± 5 | 23 ± 7 | 0.003 |
| Medications, Medical History and H2FPEF Score | |||
| ACE/ARB (%) | 14 | 75 | <0.001 |
| CCB (%) | 7 | 36 | <0.001 |
| Diuretic Agent (%) | 0 | 71 | <0.001 |
| Beta-blocker (%) | 54 | 81 | 0.12 |
| Statin (%) | 46 | 75 | 0.12 |
| Diabetes (%) | 14 | 69 | 0.03 |
| Atrial Fibrillation (%) | 0 | 31 | 0.05 |
| CAD Severity (# vessels) | 3.0 ± 0.6 | 3.2 ± 0.8 | 0.55 |
| H2FPEF Score | 2.0 ± 1.2 | 5.1 ± 1.7 | <0.001 |
| Echocardiography | |||
| EF (%) | 60 ± 5 | 59 ± 7 | 0.96 |
| Septal Wall (mm) | 10.0 ± 1.3 | 13.6 ± 1.9 | <0.001 |
| Posterior Wall (mm) | 8.4 ± 0.6 | 12.1 ± 1.4 | <0.001 |
| LVEDD (mm) | 49 ± 5 | 48 ± 5 | 0.49 |
| LVESD (mm) | 32 ± 5 | 32 ± 7 | 0.95 |
| RWT | 0.35 ± 0.03 | 0.52 ± 0.10 | <0.001 |
| LVmass (gr) | 163 ± 33 | 244 ± 45 | <0.001 |
| LVmass / BSA (gr/m2) | 82 ± 14 | 111 ± 22 | <0.001 |
| LVmass / H (gr/m) | 96 ± 17 | 144 ± 25 | <0.001 |
| LVmass / H2.7 | 40 ± 7 | 60 ± 13 | <0.001 |
| LA volume (ml) | 44 ± 9 | 79 ± 36 | 0.002 |
| LA volume / BSA | 22 ± 5 | 36 ± 15 | 0.004 |
| E (cm/sec) | 66 ± 12 | 88 ± 26 | 0.01 |
| A (cm/sec) | 79 ± 20 | 82 ± 29 | 0.76 |
| E/A ratio | 0.9 ± 0.4 | 1.1 ± 0.3 | 0.21 |
| E/E’ med | 8.6 ± 4.1 | 17.6 ± 8.0 | 0.002 |
| E/E’ lat | 8.0 ± 2.2 | 14.2 ± 8.8 | 0.02 |
BMI, body mass index; BSA, body surface area; SBP, systolic blood pressure; DBP, diastolic blood pressure; ACE/ARB, ACE-inhibitor/Angiotensin Receptor Blocker; CCB, Calcium Channel Blocker; LVEDP, left ventricular end-diastolic pressure; CAD, coronary artery disease; EF, ejection fraction; LVEDD, left ventricular end-diastolic diameter; LVESD, left ventricular end-systolic diameter; RWT, relative wall thickness; LVmass, left ventricular mass; LVmass/H, left ventricular mass to height ratio; LVmass/H2.7, allometric left ventricular mass index; LA, left atrial; E, E-wave peak velocity; A, A-wave peak velocity; E/E’med, ratio of mitral peak velocity of early filling (E) to early diastolic septal mitral annular velocity (E’), E/E’lat, ratio of mitral peak velocity of early filling (E) to early diastolic lateral mitral annular velocity;
Median (Interquartile Range) Mann Whitney U test.