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. 2023 Aug 1;13:1229696. doi: 10.3389/fonc.2023.1229696

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Copyright © 2023 Zhou, Chai, Wang, Neeli, Yu, Davtyan, Young and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification small compounds targeting p53-Y220C. (A) Workflow of artificial intelligence (AI)-powered drug screening. (B) Cell viability normalized to the vehicle control of cell lines treated for 48 h with the indicated compounds. Error bars represent the mean ± standard deviation (SD). p53-Y220C protein 2D image was obtained from the Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) with the ID of 6GGB (22).