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. 2023 Aug 1;13:1229696. doi: 10.3389/fonc.2023.1229696

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Copyright © 2023 Zhou, Chai, Wang, Neeli, Yu, Davtyan, Young and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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H3 activates p53 target gene expression. (A–C) Immunoblotting to determine the protein levels of the indicated p53 targets after H3, H9, and PK083 treatment for 24 h. (D) Quantitative polymerase chain reaction (qPCR) determination of the mRNA levels of the indicated p53 targets after H3 and PK083 treatment for 24 h. Quantitative reverse transcription (qRT)-PCR analyses results were normalized using glyceraldehyde 3-phosphate dehydrogenase (GAPDH) as an internal control gene. The fold-change in each gene was calculated using the 2^−ΔΔ ^CT method. Error Bars in (D) represent the mean ± SD. p values were calculated using two-way ANOVA analysis followed by Dunnett’s multiple-comparison test. *p<0.05, **p<0.01, ***p<0.001, and ****p<0.0001.