Fig. 3.
Plasma fibrinogen change after a single administration of fibrinogen concentrate or cryoprecipitate. Cryoprecipitate, n=225; fibrinogen concentrate, n=252. (a) Change in plasma fibrinogen concentration after a single dose of fibrinogen concentrate, adjusted for total body weight (kg) (n=252). Parameter estimate for fibrinogen concentrate per mg kg−1: 0.01 (95% confidence interval [CI], 0.007–0.016); P<0.0001. (b) Change in plasma fibrinogen concentration after a single dose of cryoprecipitate, adjusted for total body weight (per 10 kg) (n=225). Parameter estimate for cryoprecipitate per 10 kg: 0.45 (95% CI, 0.28–0.62); P<0.0001. (c) Box plot of change in plasma fibrinogen concentration after a single product dose. Wilcoxon signed-rank test P-value <0.0001. (d) Histogram of individual plasma fibrinogen changes after a single product dose. Superimposed data distributions are shown using kernel density estimates.